By A. MAzUR AND A. CARLETON T HE RESULTS of studies in our laboratory’ lend support to the hypothesis that the release of iron from ferritin stores in the liver is mediated by the enzyme xanthine oxidase acting as a dehydrogenase. In this reaction the reduced enzyme, formed as a result of oxidation of xanthine or hypoxanthine to uric acid, is reoxidized by some of the ferric iron of ferritin wh...

By A. MAzUR AND A. CARLETON T HE RESULTS of studies in our laboratory’ lend support to the hypothesis that the release of iron from ferritin stores in the liver is mediated by the enzyme xanthine oxidase acting as a dehydrogenase. In this reaction the reduced enzyme, formed as a result of oxidation of xanthine or hypoxanthine to uric acid, is reoxidized by some of the ferric iron of ferritin wh...

By A. MAzUR AND A. CARLETON T HE RESULTS of studies in our laboratory’ lend support to the hypothesis that the release of iron from ferritin stores in the liver is mediated by the enzyme xanthine oxidase acting as a dehydrogenase. In this reaction the reduced enzyme, formed as a result of oxidation of xanthine or hypoxanthine to uric acid, is reoxidized by some of the ferric iron of ferritin wh...

By A. MAzUR AND A. CARLETON T HE RESULTS of studies in our laboratory’ lend support to the hypothesis that the release of iron from ferritin stores in the liver is mediated by the enzyme xanthine oxidase acting as a dehydrogenase. In this reaction the reduced enzyme, formed as a result of oxidation of xanthine or hypoxanthine to uric acid, is reoxidized by some of the ferric iron of ferritin wh...

This study was directed to the ability of oxygen free radicals to cause reversible vascular endothelial cell dysfunction. A well-characterized system for the production of the superoxide anion radical (O2(-).) and hydrogen peroxide (H2O2), employing xanthine and xanthine oxidase, was used to sublethally injure human umbilical vein endothelial (HUVE) cells in vitro. We examined the effects of a ...