نتایج جستجو برای: xlf
تعداد نتایج: 235 فیلتر نتایج به سال:
The High Performance Fortran (HPF) benchmark suite HPFBench was designed for evaluating the HPF language and compilers on scalable architectures. The functionality of the benchmarks covers scientific software library functions and application kernels. In this paper, we report on an evaluation of two commercial HPF compilers, namely, xlhpf from IBM and pghpf from PGI, on an IBM SP2 using the lin...
Repair of DNA double-strand breaks (DSBs) is essential for genomic stability. The most common DSB repair mechanism in human cells, non-homologous end joining (NHEJ), rejoins broken DNA ends by direct ligation. It remains unclear how components of the NHEJ machinery assemble a synaptic complex that bridges DNA ends. Here, we use single-molecule imaging in a vertebrate cell-free extract to show t...
Non-homologous end joining (NHEJ) is an important DNA repair pathway for DNA double-strand breaks. Several proteins, including Ku, DNA-PKcs, Artemis, XRCC4/Ligase IV and XLF, are involved in the NHEJ for the DNA damage detection, DNA free end processing and ligation. The classical model of NHEJ is a sequential model in which DNA-PKcs is first recruited by the Ku bound DNA prior to any other rep...
ABSTRACT We analyse all the available Chandra observations of Cartwheel galaxy and its compact group, taken between 2001 2008, with main aim addressing variability in X-ray band for this spectacular collisional ring galaxy. focus on study point-like sources, particular we are interested ultraluminous sources (ULXs; LX ≥ 1039 erg s−1), that treat as a class. exploit archival XMM–Newton data to e...
DNA double-strand breaks (DSBs) occur at random upon genotoxic stresses and represent obligatory intermediates during physiological DNA rearrangement events such as the V(D)J recombination in the immune system. DSBs, which are among the most toxic DNA lesions, are preferentially repaired by the nonhomologous end-joining (NHEJ) pathway in higher eukaryotes. Failure to properly repair DSBs result...
In mammals, the majority of DNA double-strand breaks are processed by the nonhomologous end-joining (NHEJ) pathway, composed of seven factors: Ku70, Ku80, DNA-PKcs, Artemis, Xrcc4 (X4), DNA-ligase IV (L4), and Cernunnos/XLF. Cernunnos is part of the ligation complex, constituted by X4 and L4. To improve our knowledge on the structure and function of Cernunnos, we performed a systematic mutagene...
The X-ray luminosity function (XLF) of galaxies is dominated by AGN (classified by their optical spectra) above Lx = 10 42 erg s , below this value by normal galaxies. The X-ray flux of AGN at low X-ray luminosity therefore contains contributions from stellar processes (winds, supernova explosions etc.). Until now it is not clear which fraction of the observed X-ray flux has to be associated to...
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