Zoledronic acid (ZA) is commonly used for the prevention of skeletal-related events (SREs) in patients with bony metastases. ZA is a bisphosphonate that inhibits osteoclasts, possibly through inhibition of proto-oncogenic Ras activity in osteoclasts by interfering with normal post-translational modifications of Ras. This would suggest that ZA could induce an objective tumor response in metastat...

Povzetek. Zanesljivost samodejnega razpoznavanja obrazov je odvisna od številnih dejavnikov, med katerimi so najpomembnejši natančnost določitve slikovnega območja obraza in njegova odpornost na slabšo kakovost slik, izbira ustreznega postopka izpeljave obraznih značilk ter uporaba primernega algoritma za izračun podobnosti in sprejetje odločitve o identiteti osebe. V članku predstavljamo rezul...

Uslijed porasta broja korisnika i intenzivnog korištenja frekvencijskog VHF područja javila se potreba za povećanjem njegova kapaciteta. Također, javljaju se i potrebe za novim vrstama usluga, kao što je prijenos podataka, što postojeći analogni sustavi ne mogu uspješno podržati. Stoga su u ovome radu analizirana obilježja relevantnih kopnenih digitalnih komu ni­ kacijskih sustava s ciljem utvr...

The epithelial zonula adherens (ZA) is a specialized adhesive junction where actin dynamics and myosin-driven contractility coincide. The junctional cytoskeleton is enriched in myosin II, which generates contractile force to support junctional tension. It is also enriched in dynamic actin filaments, which are replenished by ongoing actin assembly. In this study we sought to pursue the relations...

Povzetek. V prispevku je predstavljena uporaba nelinearnih dinamičnih sistemov za izvajanje ritmičnih nalog. Za nalogo je bila izbrana naprava jojo. To je naprava, sestavljena iz dveh diskov, povezanih s tanko osjo. Vodenje naprave jojo je nelinearna dinamična naloga in zahteva nenehno adaptacijo frekvence izvajanja. Za vodenje te naloge je bil uporabljen imitacijski sistem, ki je sestavljen iz...

BACKGROUND Although the loss of bone mineral density (BMD) after total hip arthroplasty (THA) is a known problem, it remains unresolved. This study prospectively examined the effect of zoledronic acid (ZA) on bone turnover and BMD after cementless THA. METHODS Between January 2010 and August 2011, 60 patients who underwent cementless THA were randomly assigned to receive either ZA infusion or...

Bisphosphonates are widely used in the treatment of osteoporosis. The Intravenous bisphosphonate, Zoledronic acid (ZA) does not cause the gastrointestinal side effects associated with oral bisphosphonates and can be given as a once yearly infusion. ZA has the rare potential to cause hypophosphatemia. However, when reported, the hypophosphatemia following ZA infusion has been in the setting of t...

Povzetek. V članku sta predstavljeni implementacija in uporaba prosto dostopnega operacijskega sistema realnega časa na robotskem krmilniku DSP-2. Vgrajeni robotski krmilnik, ki je bil razvit na Fakulteti za elektrotehniko računalništvo in informatiko Univerze v Mariboru, se uporablja pretežno v pedagoškem procesu za vodenje večosnih mehanizmov. Dodatno je bila k sami implementaciji operacijske...

The present case underwent right laparoscopic radical nephrectomy for collecting duct carcinoma (CDC). Recurrence occurred in the lung and the bone (skull and lumber vertebra) in 2011. Gemcitabine plus cisplatin (GC) chemotherapy and monthly zoledronic acid (ZA) was then started. The massive skull bone metastases were prominently reossified after several courses of the therapy. The patient rece...

Rho kinases (ROCK1 and ROCK2) function downstream of the small GTPase RhoA to drive actomyosin cytoskeletal remodeling. It has often been believed that ROCK1 and ROCK2 may be functionally redundant, as they share a highly conserved kinase domain. However, in this study, we report differential functional effects for these ROCKs at the epithelial zonula adherens (ZA). Using specific siRNA, we fou...