BACKGROUND Mechanical properties and cyto-compatibility of a composite scaffold which possessed negative (-) Poisson's ratio (NPR) was investigated for effective load transfer from auxetic scaffold to cell. METHODS Organic/inorganic composite scaffolds were prepared by mixing hydroxyapatite (HA) to poly(lactide-co-glycolide) (PLGA). To induce NPR in composite scaffold, 3-directional volumetri...

Mesoporous silica-based materials are currently being explored as a new type of bioscaffold for bone regeneration applications. Zinc(Zn) ion incorporation is shown to play an important role in promoting and also providing antimicrobial activity the scaffold materials. In this work, pore size, geometry, ordered structure on Zn loading release performance two different mesoporous silica, SBA-1 SB...

In this study, mechanical properties and apatite formation ability of synthesized fluorapatite-hardystonite (FA-HT) nanocomposite scaffolds were investigated. Hardystonite (HT; 5 and 10 wt.%) as a reinforcement phase was incorporated into the FA scaffold. FA was mixed with HT for 4 h under argon gas at 220 °C. A space holder method was used for fabricating porous FA-HT scaffolds. Sodium chlorid...

Background: Spinal cord has a limited capacity to repair therefore, medical interventions are necessary for treatment of injuries. Transplantation of Schwann cells has shown a great promising result for spinal cord injury (SCI). However, harvesting Schwann cell has been limited due to donor morbidity and limited expansion capacity. Furthermore, accessible sources such as bone marrow stem cells ...

Background and Objective: Umbilical Cord blood (UCB) hematopoietic stem cell (HSC) transplantation is a therapeutic approach for the treatment of malignant and non-malignant hematologic disorders due to ease of collection, lack of risk for donors and lower levels of infection. Moreover, it is considered a good alternative for bone marrow HSC transplantation. The main limitation of their use is ...

Avulsed teeth that are replanted dried are more prone to loss. Recent tissue engineering studies focus onfabrication of various cell delivery systems to improve the overall prognosis of such teeth. To evaluate this newcell transplant method, we initially aimed at designing of PRF scaffold and determining BMMSCs viabilityand function on the fabricated scaffold. To test this concept in-vitro, hum...

Background & Aims: Tissue engineering using somatic cells and synthetic extracellular matrix (scaffold) represents a new approach for regeneration of mineralized tissue and bone. This study was carried out to investigate the ability of a PLLA/HA scaffold to culture osteoblast cells in a three dimensional milieu. Method: Three bony samples were taken from extraction sites during surgical extract...

The aim of this study was to investigate the interactions between rat intestine decellularized scaffold and human adipose derived mesenchymal stem cells. Rat large intestine was dissected in fragments and decellularized by physicochemical methods. The scaffolds were loaded by human adipose derived mesenchymal stem cells expressing green fluorescent protein. Microscopic sections were prepared fr...