BACKGROUND Zinc supplementation can reduce subsequent morbidity in children recovering from diarrhoea and respiratory illness in developing countries. However, whether routine supplementation would decrease morbidity and mortality in populations with zinc deficiency is unclear. We assessed the effect of daily zinc supplementation on children in southern Nepal. METHODS We did a community-based...

BACKGROUND Highly effective antiviral treatment can suppress HIV-1 infection, but the chronic effects of HIV-1-related viral proteins, including gp120 and Tat, on organs such as the lungs can be damaging. HIV-1 transgenic rodent models are useful for studying the systemic effects of these proteins independently of viral infection. We have previously shown that HIV-1 transgene expression (and th...

  Abstract   Objective: To determine the effect of oral zinc sulfate supplementation given with   coamoxiclav when compared with coamoxiclav alone for treatment of otitis media   with effusion (OME). The efficacy of the drug was assessed 3 and 6 weeks after administration .   Methods: In a double-blind, randomized trial 4 to 14 years old children with OME   who referred to ear, nose and throat ...

Bao S, Liu M-J, Lee B, Besecker B, Lai J-P, Guttridge DC, Knoell DL. Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NFB. Am J Physiol Lung Cell Mol Physiol 298: L744–L754, 2010. First published March 5, 2010; doi:10.1152/ajplung.00368.2009.—Zinc is an essential element that facilitates coordination of immune activation during the host response to...

BACKGROUND Low concentrations of nitric oxide (NO) are necessary for the biology and physiology of spermatozoa, but high levels of NO are toxic and have negative effects on sperm functions. Although several studies have considered the relationship between infertility and semen NO concentrations, no study on the effects of asthenospermia treatments such as oral zinc supplementation on concentrat...

This study was conducted to evaluate the effects of dietary supplement-ation of rosemary essential oils (REO) and zinc (as zinc sulfate) on performance, egg quality traits, and some serum biochemical metabolites of laying hens. A total of 144 44-weeks-old Lohmann LSL-Lite laying hens were randomly allocated into four treatments, each comprising six replicates of six birds. The first group was s...

Zinc deficiency is prevalent throughout the world, including the USA. Severe and moderate deficiency of zinc is associated with hypogonadism in men. However, the effect of marginal zinc deficiency on serum testosterone concentration is not known. We studied the relationship between cellular zinc concentrations and serum testosterone cross-sectionally in 40 normal men, 20 to 80 y of age. In four...

Zinc plays critical roles during embryogenesis, fetal growth, and milk secretion, which increase the zinc need for pregnancy and lactation. Increased needs can be met by increasing the dietary zinc intake, along with making homeostatic adjustments in zinc utilization. Potential homeostatic adjustments include changes in circulating zinc, increased zinc absorption, decreased zinc losses, and cha...

BACKGROUND Rates of mental illness in children are increasing throughout the world. Observational studies of depression, anxiety, and attention-deficit hyperactivity disorder suggest that zinc is an alternative treatment. OBJECTIVE We examined the effect of zinc supplementation on the mental health of school-age children in Guatemala. DESIGN From January to October 2006, we conducted a 6-mo...