Objective(s):The neuroprotective effect offruit aqueous extract of Ziziphus jujuba Lam on glucose-induced neurotoxicity in PC12 cells as an appropriate in vitro model of diabetic neuropathy was investigated. Materials and Methods: Cell viability was determined by the MTT assay. Cellular reactive oxygen species (ROS) generation was measured by DCFH-DA analysis. Cleaved caspase-3, a biochemical p...

Background: Medicinal plants have gained prime importance in treating several fatal diseases, such as cancer, diabetes, and eczema, because they are a rich source of bioactive phytochemicals safer alternative to synthesized chemical compounds. Genus Ziziphus Mill. belongs the family Rhamnaceae, which comprises 100 accepted plant species is well known for multipurpose applications food, fodder, ...

Objective: Ziziphus jujuba stimulates the release of nitric oxide (NO).  Because NO is involved in cardiovascular regulations, in this study the effects of hydroalcoholic extract of Z. jujuba on cardiovascular responses in acute NG-nitro-L-arginine methyl ester (L-NAME) hypertensive rats were evaluated. Materials and Methods: Rats were divided into 6 group (n=6): 1) saline, 2) L-NAME received (...

Understanding how soil water source is used spatiotemporally by tree species and if native can successfully coexist with introduced crucial for selecting afforestation. In the rocky mountainous areas of Taihang Mountains, alien Robinia pseudoacacia L. has been widely afforested into shrublands dominated Ziziphus jujuba Mill var. spinosa Vitex negundo heterophylla to improve forest coverage nutr...

Plant metallothioneins (MTs) are a family of low molecular weight, cysteine-rich, and metal-binding proteins, which play an important role in the detoxification of heavy metal ions, osmotic stresses, and hormone treatment. Sequence analysis revealed that the open-reading frame (ORF) of ZjMT was 225 bp, which encodes a protein composed of 75 amino acid residues with a calculated molecular mass o...