The Notch pathway regulates cell fate determination in numerous developmental processes. Here we report that Notch2 acts non-redundantly to control the processes of nephron segmentation through an Rbp-J-dependent process. Notch1 and Notch2 are detected in the early renal vesicle. Genetic analysis reveals that only Notch2 is required for the differentiation of proximal nephron structures (podocy...

The electrogenesis of synaptically activated dendritic Ca2+-mediated potentials, which may contribute to synaptic signal integration in pyramidal cells, was examined in rat layers V-VI prefrontal cortical (PFC) neurons in vitro. Intrasomatically recorded suprathreshold synaptic responses evoked by stimulation of the distal dendrites were attenuated by focal Cd2+ application to the proximal apic...

we introduce a new concept of general $g$-$eta$-monotone operator generalizing the general $(h,eta)$-monotone operator cite{arvar2, arvar1}, general $h-$ monotone operator cite{xiahuang} in banach spaces, and also generalizing $g$-$eta$-monotone operator cite{zhang}, $(a, eta)$-monotone operator cite{verma2}, $a$-monotone operator cite{verma0}, $(h, eta)$-monotone operator cite{fanghuang}...

background: osteoporosis is a chronic disease that contributes substantially to decrease physical activity and decline in the quality of life. osteoporosis can be diagnosed easily with the use of dual-energy x-ray absorptiometry (dxa) equipment. the aim of this study was to investigate the magnitude of bone loss on proximal femur and lumbar spine ls in pre- and post-menopausal women from isfaha...

introduction: intramedullary nailing (imn) of high tibia fracture has some mechanical and biological advantages over the other form of fixation. however, valgus, apex anterior malalignment and anterior displacement of proximal fragment commonly occur after isolated imn fixation of proximal high tibia fracture. the purpose of this study is to determine the effectiveness of using 3.5-mm locking c...

OBJECTIVES The purpose of this study was to assess local release of C-reactive protein (CRP) from atherosclerotic plaques or the vessel wall injured by stenting. BACKGROUND Recent research has focused on the local production of CRP, especially in inflammatory atherosclerotic plaques. METHODS The study consisted of two separate protocols. In protocol 1, we measured serum high-sensitivity-CRP...

Our laboratory has shown that dopamine D(2)-like receptor activation causes stimulation of Na(+), K(+)-ATPase (NKA) activity in the proximal tubules of the rat kidney. The present study was designed to investigate the cellular signaling mechanisms mediating this response to D(2)-like receptor activation. We measured the stimulation of NKA activity by bromocriptine (D(2)-like receptor agonist) i...