Objective(s): It is generally believed that the inflammatory response in bone marrow mesenchymal stem cells (BMSCs) transplantation leads to poor survival and unsatisfactory effects, and is mainly mediated by cytokines, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α). In this study, we explored the mechanisms underlying the TNF-α-induced inflammatory ...

T HE diagnostic value of serum α-protryptase levels in patients with suspected systemic mastocytosis was evaluated. The retrospective study included 22 patients with suspected mastocytosis and 30 with suspected anaphylaxis. All patients had high total serum tryptase levels of 20 ng/mL or greater and normal or slightly elevated serum β-tryptase levels--no higher than 5 ng/mL. Biopsy results were...

PURPOSE To evaluate the proinflammatory effect and molecular mechanism of IL-17 in the intestinal epithelial cell line HT-29. METHODS After culture of HT-29 cells with IL-17 and/or TNF-(α), real-time (RT) PCR and Western blot were used to measure the gene expression level of the neutrophil chemokines CXCL1, CXCL2, CXCL5, CXCL6, IL-8 and the Th-17 chemokine CCL20, the phosphorylation level of ...

it is believed that the inhibition of carbohydrate hydrolyzing enzymes including α-amylase and α-glucosidase is one of the therapeutic approaches to decrease the postprandial glucose level after a meal, especially in the people with type 2 diabetes. medicinal plants and their extracts are one of the main sources to find new inhibitors to the enzymes. in our study four flavonoids, namely luteoli...

Locus control regions (LCRs) are cis-acting gene regulatory elements with the unique, integration site-independent ability to transfer the characteristics of their locus-of-origin's gene expression pattern to a linked transgene in mice. LCR activities have been discovered in numerous T cell lineage-expressed gene loci. These elements can be adapted to the design of stem cell gene therapy vector...

It is believed that the inhibition of carbohydrate hydrolyzing enzymes including α-amylase and α-glucosidase is one of the therapeutic approaches to decrease the postprandial glucose level after a meal, especially in the people with type 2 diabetes. Medicinal plants and their extracts are one of the main sources to find new inhibitors to the enzymes. In our study four flavonoids, namely luteoli...

Finding minimum number of connecting lines is as important as locating power quality monitors (PQMs) for full observability of power system. Therefore, a PQM placement method should determine both optimum buses and lines, since utilities can make better decisions for monitoring of power system with this information. This paper attempted to propose a new method to locate the PQMs at various unob...