The first asymmetric synthesis of α-allyl-α-aryl α-amino acids by means of a three-component coupling of α-iminoesters, Grignard reagents, and cinnamyl acetate is reported. Notably, the enolate from the tandem process provides a much higher level of reactivity and selectivity than the same enolate generated via direct deprotonation, presumably due to differences in the solvation/aggregation sta...

alpha toxin derived from clostridium perfringens was used for diagnosis of streptococcus agalactiae (st.agalactiae) by rapid and spot camp tests. the selected cl.perfringens strain was cultured in optimized conditions; the supernatant of culture was concentrated by ultra filter and purified by deae cellulose chromatography. the efficacy of both purified and crude α-toxins were examined by rapid...

background:chronic active adrenocorticotropin hormone (acth) immunization of ewes (with a previous history of immunization) resulted in elevated titres of antibody against acth, which induced a reduction in circulating levels of cortisol. objectives:the aim of the present study was to investigate: a) the influence of active immunization against acth on milk production of the ewe as assessed by ...

a fibroadenoma was diagnosed in the mammary gland of a lamb by immunohistochemical method andmeasurement of oestradiol hormone. the tumor was characterized by an encapsulated firm mass with acreamy-white cut surface. histologically, it consisted of variably-sized sinus ducts, covered by a single ormultiple layers of proliferated epithelial cells, and embedded in a loose connective tissue. immun...

biochemical characteristics of α-amylase in the digestive system and head glands of cryptolaemus montrouzieri, a key predator of citrus mealybug, planococcus citri (pseudococcidae), were studied. the major isoform of α-amylase with the same molecular weight was detected in both gut and head glands loaded on polyacrylamide-starch gel electrophoresis. moreover, a minor band with much lower intens...

background pompe disease is an inherited metabolic disorder characterized by α-glycosidase deficiency, which leads to lysosomal glycogen accumulation in many different tissues. the infantile form is the most severe with a rapidly fatal outcome, while the late onset form has a greater phenotypic variability, characterized by skeletal muscle dysfunction and early respiratory involvement. bone min...

α-Tocopheryl succinate (α-TS) and α-tocopheryloxyacetic acid (α-TEA) are potent inducers of apoptosis in cancer cells efficient suppressors tumors experimental model cell lines. They exhibit selective cytotoxicity against tumor very limited or no toxicity toward nonmalignant cells. In the present work, a series new α-tocopherol derivatives were synthesized as analogs α-TS α-TEA. The cytotoxic a...