β-lactamase hydrolyses amide bond of β-lactam ring. antibiotics are the main arsenal in antibiotic regime. High degree mutation and genetic variation enzymes have elevated resistance towards inhibitors. There 4 classes β-lactamase, namely Class A, C, D which Serine proteases B is Metallo proteases. The most documented one TEM, where water molecules (315, 319, 440, 441) play an important role bi...

Kingella kingae is a human pathogen that causes pediatric osteoarticular infections and infective endocarditis in children and adults. The bacterium is usually susceptible to β-lactam antibiotics, although β-lactam resistance has been reported in rare isolates. This study was conducted to identify β-lactam-resistant strains and to characterize the resistance mechanism. Screening of a set of 90 ...

An Ambler class A β-lactamase gene, bla(CIA-1), was cloned from the reference strain Chryseobacterium indologenes ATCC 29897 and expressed in Escherichia coli BL21. The bla(CIA-1) gene encodes a novel extended-spectrum β-lactamase (ESBL) that shared 68% and 60% identities with the CGA-1 and CME-1 β-lactamases, respectively. bla(CIA-1)-like genes were detected from clinical isolates. In addition...

extended-spectrum β-lactamase (esbl)-producing enterobacteria has become a considerable global concern because of their potential dissemination in humans, in domestic animals, wildlife and the environment. the present study aimed to explore the esbl producing  enterobacteria in aquatic sources of bangladesh as the water may be the potential source of dissemination of this alarming antimicrobial...

conclusions beside our study, the detection of mbl genes were reported in a few studies conducted in iran. the spread of detected mbls producing p. aeruginosa were unprecedented in the region due to the lack of independent related researches or the novel incidence of these genes. this detection must be noted by associated clinical and health care services. results from 240 p. aeruginosa isolate...

The β-lactamase inhibitor avibactam (NXL104) displays potent inhibition of both class A and C enzymes. The in vitro antibacterial activity of the combination ceftazidime-avibactam was evaluated against a clinical panel of Pseudomonas aeruginosa isolates. Avibactam offered efficient protection from hydrolysis since 94% of isolates were susceptible to ceftazidime when combined with 4 μg/ml avibac...

DESCRIPTION TIMENTIN is a sterile injectable antibacterial combination consisting of the semisynthetic antibiotic ticarcillin disodium and the β-lactamase inhibitor clavulanate potassium (the potassium salt of clavulanic acid) for intravenous administration. Ticarcillin is derived from the basic penicillin nucleus, 6-amino-penicillanic acid. Chemically, ticarcillin disodium is N-(2-Carboxy-3,3-...

Abstract Background Cefiderocol (CFDC) is a siderophore cephalosporin that hijacks the Gram-negative bacteria iron transport system to facilitate cell entry and reach its target. CFDC remains stable hydrolysis in presence of serine β-lactamases (ESBLs, KPC, OXA-type carbapenemases) metallo-β-lactamases (MBL). comparator activities were analyzed against Enterobacterales (ENT), including molecula...

OBJECTIVES AmpC β-lactamases are classified as Amber Class C and Bush Group 1. AmpC β-lactamases can hydrolyze broad and extended-spectrum cephalosporins, and are not inhibited by β-lactamase inhibitors such as clavulanic acid. This study was conducted to identify DHA-23, a novel plasmid-mediated and inducible AmpC β-lactamase obtained from Enterobacteriaceae. METHODS A total of 210 carbapene...