Histone modifications mediate changes in gene expression by altering the underlying chromatin structure or by serving as a binding platform to recruit other proteins. One such modification, histone methylation, was thought to be irreversible until last year when Shi and co-workers broke new ground with their discovery of a lysine-specific histone demethylase (LSD 1). They showed that LSD 1, a n...

In order to determine the distribution and function of the 5-HT5A serotonin receptor subtype, we generated knockout mice lacking the 5-HT5A gene. Comparative autoradiography studies of brains of wild-type (wt) and 5-HT5A knockout (5A-KO) mice revealed the existence of binding sites with high affinity for [125I]LSD that correspond to 5-HT5A receptors and that are concentrated in the olfactory bu...

Twenty-one recreational polydrug users (age range: 17±34 years), were recruited into the study using the `snowball' technique (Solowij et al., 1992). All had used MDMA (3,4-methylenedioxymethamphetamine, or `Ecstasy'), LSD (lysergic acid diethylamide), and amphetamine, on di€erent occasions. They completed modi®ed Pro®le of Mood States Questionnaires, to indicate their typical feeling states wh...

A Dietilamida do Ácido Lisérgico (LSD) é uma substância psicoativa, capaz de causar mudanças cognitivas. Ganhou notoriedade nos anos 1960, sendo interligada à cultura hippie. Seu uso foi proibido e considerado nocivo população, gerando estigmas preconceitos acerca substâncias psicoativas no geral. O objetivo levantar opiniões a respeito terapêutico LSD. Trata-se pesquisa qualitativa com entrevi...

-Rats were trained on a multiple schedule of poskive reinforcement. A stimulus light source flickering at 100 eye!e/see provided the discriminative stimulus (Sa). Under the Sa cvndidon, reir, forcemer_t was contingent upon an FRI0 _chedule. Tke same light source flickering at 30 cycle/see constituted the S_ condition. Brom-lysergic acid diethyb amide (BOL), at doses of 1 and 3/_mol/kg had no ef...

The co-administration of D-lysergic acid diethylamide (LSD; 'Acid') and 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy'; 'XTC'), has reached a prevalence that has allowed for the street terminology 'candyflipping' to describe the combination. Internet sites indicate a significant enhancement of central effects with their simultaneous use. In this preliminary observation, male Fawn-Hooded rat...

We propose clustering samples given their pairwise similarities by factorizing the similarity matrix into the product of a cluster probability matrix and its transpose. We propose a rotation-based algorithm to compute this left-stochastic decomposition (LSD). Theoretical results link the LSD clustering method to a soft kernel k-means clustering, give conditions for when the factorization and cl...

Purpose: The aim of the study was to evaluate the mucosal immune function and circadian variation of salivary cortisol, Immunoglobin-A (sIgA) secretion rate and mood during a period of high-intensity interval training (HIIT) compared to long-slow distance training (LSD). Methods: Recreational male runners (n = 28) completed nine sessions of either HIIT or LSD within 3 weeks. The HIIT involved 4...

Information concerning the plhotoperio(lic response of Cestrum isocturnums L. was initially reported by Sachs (4). From his investigation he found it was a long-short day (LSD) plant and, under experimental conditions he used, did not produce floral primordia in response to other light patterns. More recent work with C. niocturnunti confirmed the previously reported LSD response but added that ...

Non-coding RNAs (ncRNAs) are a functional class of RNA involved in the regulation of several cellular processes which may modulate disease onset, progression, and prognosis. Lysosomal storage diseases (LSD) are a group of rare disorders caused by mutations of genes encoding specific hydrolases or non-enzymatic proteins, characterized by a wide spectrum of manifestations. The alteration of ncRNA...