We investigated the anatomical and functional organization of the human substantia nigra (SN) using diffusion and functional MRI data from the Human Connectome Project. We identified a tripartite connectivity-based parcellation of SN with a limbic, cognitive, motor arrangement. The medial SN connects with limbic striatal and cortical regions and encodes value (greater response to monetary wins ...

OBJECTIVE The purpose of this study was to evaluate, by means of cephalometric appraisal, the vertical effects of non-extraction treatment of adult anterior open bite with clear aligners (Invisalign system, Align Technology, Santa Clara, CA, USA). METHODS Lateral cephalograms of 30 adult patients with anterior open bite treated using Invisalign (22 females, 8 males; mean age at start of treat...

Shengjiang Xiexin decoction (SXD), a classic traditional Chinese medical formula chronicled in Shang Han Lun, is used in modern clinical practice to decrease gastrointestinal toxicity induced by the chemotherapeutic drug irinotecan (CPT-11). In this study, the effect of SXD on the pharmacokinetics of CPT-11 and its active metabolites (SN-38 and SN-38G), and the underlying mechanisms were furthe...

There is a growing number of supernovae (SNe), mainly of Type IIn, which present an outburst prior to their presumably final explosion. These precursors may affect the SN display, and are likely related to some poorly charted phenomena in the final stages of stellar evolution. Here we present a sample of 16 nearby Type IIn SNe for which we have Palomar Transient Factory (PTF) observations obtai...

Aims. Long-duration gamma-ray bursts (GRBs) have been found to be associated with broad-lined type-Ic supernovae (SNe), but only a handful of cases have been studied in detail. Prompted by the discovery of the exceptionally bright, nearby GRB 130427A (redshift z = 0.3399), we aim at characterising the properties of its associated SN 2013cq. This is the first opportunity to test directly the pro...

The anticancer drug irinotecan (CPT-11) is activated to the potent topoisomerase I inhibitor, SN-38 (7-ethyl-10-hydroxycamptothecin), by esterases. SN-38 is in turn conjugated to the inactive SN-38 glucuronide (SN-38G). The reverse reaction is mediated by beta-glucuronidases. Hence, production of SN-38 may occur through either pathway. In this study we conducted in vitro studies to examine thes...

kalateh ahani is located 27 km southeast of gonabad within the khorasan razavi province. the area is part of lut block. sub-volcanic monzonitic rocks intruded regional metamorphosed shemshak formation (jurassic age). magnetic susceptibility of less altered monzonitic rocks is 0.6%., as, pb and zn > 1%, au up to 150 ppb and sn = 133 ppm. the sn content of vein in the northern part of kalateh aha...

We study in detail the algebra Sn in the title which is an algebra obtained from a polynomial algebra Pn in n variables by adding commuting, left (but not two-sided) inverses of the canonical generators of Pn. The algebra Sn is non-commutative and neither left nor right Noetherian but the set of its ideals satisfies the a.c.c., and the ideals commute. It is proved that the classical Krull dimen...

We are interested in examples of compact, complete, locally CAT(-1) spaces X, and closed totally geodesic codimension two subspaces Y , with the property that ∂∞X̃ = Sn+2 ∞ , and ∂ ∞Ỹ = Sn ∞. We show that if the inclusion S n ∞ ↪→ Sn+2 ∞ induced by the inclusion Y ⊂ X is knotted, then it is a totally wild knot (i.e. nowhere tame). We give examples where the inclusion Sn ∞ ↪→ Sn+2 ∞ is indeed kno...

We present photometric and spectroscopic observations of the Type Ib supernova (SN Ib) 1996N in NGC 1398. The supernova has been observed at several occasions between 179 and 337 days after discovery. The light curves in V , R and I have decline rates of 1.67±0.23, 1.72±0.10 and 1.93±0.24 mag (100d)−1 respectively, substantially faster than the decay rate of 56Co. The late light curves of SN 19...