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Low-grade proteinuria occurs in most patients with dis seminated cancer. Twenty-four-hr urine protein (average ± S.D.; N = 9 to 17) was <80 mg in normals; 223 ±154 mg in patients with acute myelocytic leukemia; 177 ±98 mg in subjects with Stage IV Hodgkin's; and 215 ±147, 229 ± 186, 233 ±163, and 280 ±240 mg in patients with meta static cancer of colon, breast, ovary, and pancreas, respe...
Objective—To examine the eVect of concomitant intake of â blockers with angiotensin converting enzyme (ACE) inhibitors, diuretics, or both on plasma renin concentrations in a population based sample (MONICA survey, Augsburg, Germany). Subject and methods—728 individuals were studied, of whom 171 were treated using monotherapy (ACE inhibitor (n = 21), diuretic (n = 10), or â blocker (n = 72)), o...
Libraries, Eric Elliott, Eric Hamilton, O'Reilly Media, Incorporated, 2013, 1449320945, 9781449320942, 300 pages. Take your existing JavaScript skills to the next level and learn how to build complete web scale or enterprise applications that are easy to extend and maintain. By applying the design patterns outlined in this book, youÐ2Ђ™ll learn how to write flexible and resilient code thatÐ2...
The immunization of rabbits with cells of mouse leukemia L1210 has been studied. The immune process was dissected into its †̃yMand †̃yGcomponents. The main objective was the preparation of antisera with high cytolytic potencies. A single i.v. injection of viable Ll2lO cells produced a classical immune response in rabbits, with -yM antibody activity first detected on Day 4, maximal on Day 6, a...
This paper discusses medical action, homeopathic action in particular, from a semiotic perspective. Any doctor – patient relation and communication aims at an action. Action medicine follows decision which is determined by the meaning of signs operations with signs. In their turn, are conditioned perception interpretation they have to receivers, both intra- intersubjectively. T...
Let X be a nonempty finite set, ∆(X) = { p : X → [0, 1] | Px∈X p(x) = 1}, and let % denote a binary relation on ∆(X). As usual, Â and ∼ denote the asymmetric and symmetric parts of % . In our nomenclature elements of X are outcomes (or consequences or prizes), elements of ∆(X) are lotteries, and % is the preference relation. Axioms: A1 the relation % is complete and transitive. A2 (continuity) ...
Barrett's esophagus is a premalignant condition arising in response to chronic reflux esophagitis. Inducible nitric oxide synthase (¡NOS;NOS-2) and cyclooxygenase-2 (COX-2) are mediators of inflammation and regu lators of epithelial cell growth. Expression levels of ¡NOSand COX-2 are high in colorectal adenomas and carcinomas, and COX-2 expression is elevated in gastric cancers. To determine ...
C —¿ > T transitions at CpG sites are the most prevalent mutations found in the p53 tumor suppressor gene in human colon tumors and in the germline (Li-Fraumeni syndrome). All of the mutational hot spots are methylated to 5-methylcytosine, and it has been hypothesized that the majority of these mutations are caused by spontaneous hydrolytic deamination of this base to thymine. We have previou...
The efficacy of present day antineoplastic regimens depends upon the delivery and penetration of therapeutic agents through the tumor vas cular and interstitial spaces to the tumor cell target. The distribution of relevant molecules or cells in a solid tumor is often poor and heteroge neous and is believed to be due to a number of pathophysiological factors, including elevated interstitial flui...
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