The present study aimed to analyze the characteristics of polyethylene glycol (PEG)ylated carboplatin liposomes (PL-CBPs), including size, stability, their release, entrapping and loading efficiencies, and their antitumor and antimetastatic effects on the lymph nodes. The PL-CBPs were prepared using PEG-2000 with the thin film hydration method. The liposome size and release, entrapping and load...

Piperlongumine has anti-cancer activity in numerous cancer cell lines via various signaling pathways. But there has been no study regarding the mechanisms of PL on the lung cancer yet. Thus, we evaluated the anti-cancer effects and possible mechanisms of PL on non-small cell lung cancer (NSCLC) cells in vivo and in vitro. Our findings showed that PL induced apoptotic cell death and suppressed t...

The use of a prodrug, a conjugate of an active drug with a lipophilic substituent, is a good way of increasing the cutaneous absorption of a drug. However, the activity of dermal hydrolases has rarely been investigated in humans, or experimental animals. In the present study, we focused on the identification of rat dermal esterases and the hydrolysis of a prodrug during permeation across rat sk...

The state of pregnancy is known to alter hepatic drug metabolism. Hormones that rise during pregnancy are potentially responsible for the changes. Here we report the effects of prolactin (PRL), placental lactogen (PL), and growth hormone variant (GH-v) on expression of major hepatic cytochromes P450 expression and a potential molecular mechanism underlying CYP2E1 induction by PL. In female huma...

The prosthetic leg (PL) is a typical human-machine system in which the dynamic interaction between the human body and PL (machine) determines a high requirement of ergonomics design for PL and consequently needs to consider an indicator of usability indicating the performance of gait biomechanics. How to evaluate the indexes of usability for PL products is critical to the design technology of P...

We have observed visible photoluminescence (PL) spectra (peak energy: 3.1 eV) of size-controlled silicon (Si) nanoparticles annealed in oxygen gas. The PL peak energy did not depend on the temperature, and the PL lifetime was relatively fast (on the order of nanoseconds). It was inferred that the visible PL was attributed to localized states in the oxidized surfaces of size-controlled Si nanopa...

Piperlongumine (PL) is recently found to kill cancer cells selectively and effectively via targeting reactive oxygen species (ROS) responses. To further explore the therapeutic effects of PL in cancers, we investigated the role and mechanisms of PL in cancer cell migration. PL effectively inhibited the migration of human glioma (LN229 or U87 MG) cells but not normal astrocytes in the scratch-wo...

1. Recently Kirby and Siebenmann have given general solutions of Hauptvermutung [5] and relative Hauptvermutung for neighborhoods of locally flat submanifolds [ó]. In this note we announce some results about relative Hauptvermutung for neighborhoods of 1-flat submanifolds with codimension two (compare [ l l ] and [3]). We shall say that manifold pairs (Q, M) and (Q', M') are topologically micro...

A system of PL/I procedures has been written that permits geometric objects to be described hierarchically. The objects are themselves represented as P L / I procedures, allowing very general use of variables. By effectively intercepting subprogram calls, the system provides a means of modifying the semantics associated with any object without modifying the object’s procedural description

the inheritance of cold resistance was evaluated at the germination stage in crosses between seven rice genotypes as half diallel. analysis of variance indicated that there were highly significant differences among the genotypes, general combining ability (gca) and specific combining ability (sca) for percentage of reduction in radicle length (rl), percentage of reduction in plumule length (pl)...