We have used homology modelling, based on the crystal structure of the human glutathione S-transferase (GST) A1-1, to obtain the three-dimensional structures of rat GSTA3 and rat GSTA5 subunits bound to S-aflatoxinyl-glutathione. The resulting models highlight two residues, at positions 208 and 108, that could be important for determining, either directly or indirectly, substrate specificity fo...

ابتلای یکی از اعضای خانواده به بیماری مزمن، بر روابط، نقش‌ها، سلسله مراتب و به‌طور کلی سیستم تأثیر می‌گذارد را برای مدیریت سازگاری با شرایط جدید، چالش‌هایی مواجه می‌کند. هدف این مرور ادبیات پژوهشی، شناسایی مسائلی است که در مزمن اعضا، آن رو‌به‌روست. بدین منظور، بررسی نظام‌مند مقالات چاپ‌شده زبان فارسی یا انگلیسی مجلات داخلی خارجی سال 201۴ (دی ۱۳۹۲) تاکنون، پایگاه‌های SID، Magiran، Google Scholar...

* Corresponding author. Chairman of the Accreditation Assessment Committee, Department of Cardiology, Hammersmith Hospitals NHS Trust at Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK. Tel.: C44 208 846 1917; fax: C44 208 746 8182. E-mail address: [email protected] (K.F. Fox). 1 The Accreditation Assessment Committee of the European Association of Echocardiography. 2 President...

Caspase-3 is a critical effector caspase in apoptosis cascade, and is often over-expressed in many cancer tissues. The first synthesized procaspase-3 activator, PAC-1, induces cancer cell apoptosis and exhibits antitumour activity in murine xenograft models. To identify more potent procaspase-3 activators, a series of compounds were designed, synthesized and evaluated for their ability of induc...

Endoplasmic reticulum (ER) oxidoreductin 1α (Ero1α) is a disulfide producer in the ER of mammalian cells. Besides four catalytic cysteines (Cys(94), Cys(99), Cys(394), Cys(397)), Ero1α harbors four regulatory cysteines (Cys(104), Cys(131), Cys(208), Cys(241)). These cysteines mediate the formation of inhibitory intramolecular disulfide bonds, which adapt the activation state of the enzyme to th...

1Department of Mathematics & Statistics, Indian Institute of Technology, Kanpur 208 016, India 2Department of Mathematics, The LNM Institute of Information Technology, Jaipur 302 031, India 3TIFR Centre For Applicable Mathematics, Tata Institute of Fundamental Research, Bangalore 560 065, India 4Department of Aerospace Engineering, Indian Institute of Technology, Kanpur 208 016, India *Correspo...