Abstract As reported in previous studies, the processing of Mo–Si–B alloys using additive manufacturing (AM) techniques, like directed energy deposition (DED) shows a high technical feasibility. The present work investigates cyclic oxidation performance an AM DED Mo–9Si–8B alloy. Depending on temperature (800 °C, 1100 1300 °C), mechanisms vary, which is due to different reactions at surface acc...

OBJECTIVE Digital retinal imaging is an established method of screening for diabetic retinopathy (DR). It has been established that currently about 1% of the world's blind or visually impaired is due to DR. However, the increasing prevalence of diabetes mellitus and DR is creating an increased workload on those with expertise in grading retinal images. Safe and reliable automated analysis of re...

The essential targets of dry eye disease (DED) treatments include both objective signs and subjective symptoms. However, due to the numerous subjective symptoms, it is understandable why little association has been found between the signs and symptoms. Although psychological influences on the subjective symptoms have been reported, little is known about the influence of personality traits. The ...

Purpose The purpose of this study is to determine the potential of narrow spectrum kinase inhibitors (NSKIs) to treat inflammatory eye disorders. Methods Human conjunctival epithelial (HCE) cells were retrieved from subjects via impression cytology. Real-time quantitative PCR (qPCR) was performed on HCE cells to determine gene expression of NSKI kinase targets and proinflammatory cytokines in...

PURPOSE To investigate whether tear hyperosmolarity, a feature of dry eye disease (DED), affects central corneal thickness (CCT), corneal light reflectivity, and/or tear film reflectivity. METHODS This prospective, cross-sectional study involved 48 participants (38 with hyperosmolar tears and 10 controls with normo-osmolar tears). Symptoms and signs of DED (tear osmolarity, sodium fluorescein...

Purpose The objective of this study was to report the evaluation of efficacy and safety of cyclosporine A cationic emulsion (CsA CE) 0.1% for the treatment of severe keratitis in adults with dry eye disease (DED) in a French early-access program. Methods Patients with DED and severe keratitis (corneal fluorescein staining [CFS] score of 3-5 on the Oxford scale and/or the presence of corneal l...

Dry eye disease (DED) is a multifactorial disorder affecting the composition and volume of tears. DED causes ocular surface dryness, cooling, and hyperosmolality, leading ultimately to corneal epithelium damage and reduced visual performance. Ocular discomfort is the main clinical symptom in DED. However, the peripheral neural source of such unpleasant sensations is still unclear. We analyzed i...

Abstract Additive Manufacturing (AM) technologies are recognized as the future of manufacturing industry thanks to their possibilities in terms shape design, part functionality, and material efficiency. The use AM many industrial sectors is growing, also due increasing knowledge regarding processes characteristics final part. One most promising techniques Directed Energy Deposition (DED) that u...

Introduction: It is a basic principle of the "psychedelic" treatment model that the quality of the acute experience mediates long-term improvements in mental health. In the present paper we sought to test this using data from a clinical trial assessing psilocybin for treatment-resistant depression (TRD). In line with previous reports, we hypothesized that the occurrence and magnitude of Oceanic...

Abstract In this work, we demonstrate the feasibility of manufacturing an iron-based oxide-dispersion-strengthened (ODS) PM2000 composite material with chemical composition Fe20Cr4.5Al0.5Ti + 0.5Y 2 O 3 (in wt.%) via advanced directed energy deposition (DED) process high-speed laser cladding (HSLC). The characteristic high solidification rates HSLC processes allow successful dispersion nano-sca...