Plateiet monoamine ox!dase (MAO) activity was determined, using benzylainine as substract. Results are expressed as nM benzaidehyde/nig protein hour, at 37. A total of 79 diabetics (40 M and 39 F) ranging in age from 3 to 70 years was stud,ed. A normal control group inciuded 39 persons (17 M and 22 F) ranging in age from 16 to 60 years. Piatelet MAO activity shows a slight variation in relation...

In September 1937 Elvehjem et al. discovered that a single dose of 30 nig. of Eastman Kodak Company nicotinic acid improved the appetite and stopped the diarrhoea in a dog suffering from black tongue; since this date many people have treated human pellagrins with nicotinic acid. Results from this form of treatment have been sp successful that nicotinic acid is now established as a specific cure...

We compared combination therapy with low-dose aspirin plus ticlopidine to therapy with aspirin alone or ticlopidine alone in patients suffering transient ischemic attack or cerebral infarction. In 17,24, and 23 patients, respectively, 300 mg/day aspirin, 200 nig/day ticlopidine, and 81 mg/day aspirin plus 100 mg/day ticlopidine were administered orally. Aspirin alone markedly inhibited platelet...

At present probably the most popular and effective method to alleviate the withdrawal symptoms in narcotic addicts is the substitution of the stronger narcotics by methadone which because of its milder addictiveness can be more easily and rapidly withdrawn (Weiland and Chambers, 1970). However, methadone itself is an addictive drug, its abuse liability being enhanced by the fact that it can als...

nig (1973) and Peterson (1981), i.e. including Sylvicola Harris, Olbiogaster Osten Sacken, Mycetobia Meigen and related genera, are today a small family of nematocerous Neodiptera (see Michelsen 1996a) with ca. 120 species described. However, a rich fossil record suggests that the direct lineage leading to the modern family can be traced back to early Middle Mesozoic (200+ Myr). The family is r...

The results of studies on the reticulum cell sarcoma (RCS) tumors of SJL/J mice presented here, indicate that spontaneous tumors, which arise in older mice, also possess the capacity to induce the vigorous proliferative response in syngenetic T lymphocytes that are characteristic of the transplantable RCS lines. Analysis of cell surface antigens revealed the presence of Ia determinats on gradie...

A procedure is described for the direct determination of methyl derivatives of basic amino acids in total acid hydrolyzates of proteins by the use of a Beckman amino acid analyzer operated in the high sensitivity mode with automatic integration. The conditions described permit the separation of ornithine, lysine, 5-hydroxylysine, N’-monomethyllysine, N”-dimethyllysine, histidine, N’-methylhisti...

The oxidation o i low-density lipoprotein (LDL) by macrophages. smooth muscle cells antl enclothelial cells. within the vessel wall. may play a central role in the development of atherosclerotic lesions[ I]. Proposed mechanism of cell-mediated oxidation. include attack by lipoxygenases[2] or generatiori of supcroxide[3] but these mechanisms have proved controversial[4.5]. Nitric oxide protects ...

The replication of foot-and-mouth disease virus (FMDV) is dependent on the virus-encoded 3C protease (3C(pro)). As in other picornaviruses, 3C(pro) performs most of the proteolytic processing of the polyprotein expressed from the large open reading frame in the RNA genome of the virus. Previous work revealed that the 3C(pro) from serotype A-one of the seven serotypes of FMDV-adopts a trypsin-li...

A method of combining survey data and Dairy Herd Improvement Association (DHIA) records to achieve low cost farm trials is presented. Farm trials and surveys of current practices and production responses are useful to identify yield gaps between expectations predicted from experimental findings and actual field results. Different management schemes can be ranked using subjective probabilities a...