The kynurenine pathway (KP) and one of its end-products, the excitotoxin quinolinic acid (QUIN), are involved in the pathogenesis of several major neuroinflammatory brain diseases. A relevant animal model to study KP metabolism is now needed to assess whether intervention in this pathway may improve the outcome of such diseases. Humans and macaques share a very similar genetic makeup. In this s...

The kynurenine pathway (KP) is the main catabolic pathway of the essential amino acid tryptophan. The KP has been identified to play a critical role in regulating immune responses in a variety of experimental settings. It is also known to be involved in several neuroinflammatory diseases including Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. This review consider...

It is by now well known that the wave functions of rational solutions to the KP hierarchy which can be achieved as limits of the pure n-soliton solutions satisfy an eigenvalue equation for ordinary differential operators in the spectral parameter. This property is known as “bispectrality” and has proved to be both interesting and useful. In this note, it is shown that certain (non-rational) sol...

Dr. KP Srivastava was born at Gorakhpur on 5th April, 1935 He did his graduation (MBBS) and postgraduation i.e., MS (Gen Surgery) from SN Medical College, Agra. His interest in orthopaedics and trauma care took him to GSVM Medical College, Kanpur where he did his MS (Ortho) under the legendary Prof. AK Gupta. He joined the Department of Orthopaedics, SN Medical College, Agra as a lecturer in 19...

Given the two boson representation of the conformal algebra Ŵ∞, the second Hamiltonian structure of the KP hierarchy, I construct a bi-Hamiltonian hierarchy for the two associated currents. The KP hierarchy appears as a composite of this new and simpler system. The bi-Hamiltonian structure of the new hierarchy gives naturally all the Hamiltonian structures of the KP system.

INTRODUCTION Joint registries have demonstrated value as a resource for the study of large numbers of patients, providing the opportunity to study rare occurrences and identify early failures of surgical procedures. Anterior cruciate ligament (ACL) reconstruction registries have been established in Norway and the U.S. In this study, we compared the preoperative characteristics of the Norwegian ...

Our previous studies showed that kisspeptin-10 (Kp-10) injected in vivo can markedly increase lipid anabolism in liver of quails. In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from embryos livers and cultured in vitro with 0, 100 and 1,000 nM Kp-10, respectively. The results showed that after 24 h treatment, cells viability ...

The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants, kynurenic acid (KYNA) and picolinic acid (PIC), the excitotoxin, quinolinic acid (QUIN) and the essential pyridine nucleotide, nicotinamide adenine dinucleotide (NAD(+)). The enzymes indoleamine 2,3-dioxygenase-1 (IDO-1), indoleamine 2,3-dioxyg...

We study the groups Gal L (T) and Gal KP (T), and the associated equivalence relations E L and E KP , attached to a rst order theory T.

We comment on traveling wave solutions and rational solutions to the 3+1 dimensional Kadomtsev–Petviashvili (KP) equations: (ut + 6uux + uxxx)x ± 3uyy ± 3uzz = 0. We also show that both of the 3+1 dimensional KP equations do not possess the three-soliton solution. This suggests that none of the 3+1 dimensional KP equations should be integrable, and partially explains why they do not pass the Pa...