The mol-ecular structure of the title compound, C(13)H(18)N(4)O(3)S, (systematic name: ethyl N-{2-[4-(dimethyl-amino)benzo-yl]hydrazinethio-carbon-yl}carbamate) is stabilized by intra-molecular N-H⋯O=C hydrogen bonding arranged in an S(6) graph-set motif. In the crystal, inversion dimers connected via inter-molecular N-H⋯S=C hydrogen bonds [R(2) (2)(8) graph-set motif] form sheets parallel to t...

The title compound, C(8)H(9)ClN(4)S, which has potential insecticidal activity, was synthesized by the reaction of 2-chloro-5-methyl-nicotinaldehyde and thio-semicarbazide. In the crystal structure, the mol-ecules are linked via inter-molecular N-H⋯N, N-H⋯S and N-H⋯Cl hydrogen bonds, forming a three-dimensional network stacked down a.

This article describes the synthesis of six 4-aryl-(thio)semicarbazides (series a and b) linked with diphenylacetyl moiety along with their pharmacological evaluation on the central nervous system in mice and computational studies, including conformational analysis and electrostatic properties. All thiosemicarbazides (series b) were found to exhibit strong antinociceptive activity in the behavi...

Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively from thiosemicarbazide, in satisfactory yields. The structure of the compounds were elucidated by Elemental, IR, and NMR spectral data. The antibacterial activity of these compounds was tested by disc diffusion assay against two Gram-positive and two Gram-negative bacterie. The results showed t...

Condensation of ethylaceto acetate (EAA) with resorcinol in concentrated H2SO4 afforded 7-hydroxy-4-methyl coumarin (1), which on reaction with thiosemicarbazide in anhydrous pyridine yielded 7-hydroxy-4-methyl-quinolinyl [1,5-c]-mercaptotriazole (2). Reaction of 2 with formaldehyde solution and amino acid in ethanol yielded 7-hydroxy-4-methyl-8-(N-methyl-aminoacid)-quinolinyl [1,5-c]-2''-merca...

A semiorganic crystal of zinc thiosemicarbazide sulfate (ZTSCS) has been grown aqueous solution by slow evaporation technique at room temperature. The material was subjected to various characterization techniques such as UV-Visible, non linear optical test, photoluminescence study, elemental analysis and Fourier transform infrared (FTIR) techniques. Cut off wavelength and band gap of the grown ...

Abstract New thiosemicarbazone (TSC) ligands, AMT-C N-TSCH (L1), N-TSC(CH3) (L2), CIN-C (L3) and (L4) (AMT = 2-acetyl-5-methylthiophene, TSCH = thiosemicarbazide, TSC(CH3) = 4-methyl-3-thiosemicarbazide, CIN = cinnamaldehyde) were synthesized by condensation reaction. The reaction of [PdCODCl2] with the ligands L1, L2 L4in ratio 1:1 yielded complexes [Pd(L1)Cl] (C1), [Pd(L2)Cl2] (C2), [Pd(L4)2C...

   One-pot reaction of aldehydes with thiosemicarbazide was performed using NaBH4 and Fe3O4 magnetic nanoparticles (MNPs). The reaction mixture of thiosemicarbazide and carbonyl compounds was stirred under reflux condition in the present of Fe3O4 MNPs and NaBH4.The optimum amount of Fe3O4</su...

Thiosemicarbazides are potent intermediates for the synthesis of pharmaceutical and bioactive materials and thus, they are used extensively in the field of medicinal chemistry. The imine bond (-N=CH-) in these compounds are useful in organic synthesis, in particular for the preparation of heterocycles and non-natural β-aminoacids.In this paper the synthesis of some new thiosemicarbazide derivat...

Utilization of benzoxazinone for synthesis quinazolinone derivatives with 3-heterocycle side chain. treatment of benzoxazinon 1 with cyano acetohydrazide or thionocarbohydrazide gave the quinazolinone derivatives 2 or 12. quinazolinone 2 has been utilized as synthon for new  pyridinone, oxazet, thiazole, thiazolidinone and quinazolinone derivatives. Thiosemicarbazide and thiosemicarbazone deriv...