Silymarin is the active constituent of Silybum marianum (milk thistle) which is a C-25 containing flavonolignan. Milk thistle has a lot of traditional values, being used as a vegetable, as salad, as bitter tonic, and as galactogogue in nursing mothers and in various ailments such as liver complications, depression, dyspepsia, spleenic congestions, varicose veins, diabetes, amenorrhea, uterine h...

Botanical medicines have been used traditionally by herbalists and indigenous healers worldwide for the prevention and treatment of liver disease. Clinical research in this century has confirmed the efficacy of several plants in the treatment of liver disease, while basic scientific research has uncovered the mechanisms by which some plants provide their therapeutic effects. This article is Par...

Silybum marianum (L.) Gaertn. is an important medicinal plant of family Compositae, commonly known as Milk-thistle, or St. Mary’s thistle. The plant and its extracts are reported to possess hepatoprotective, antioxidant, [1] anticancer, [2] antiinflammatory and antidiabetic properties. It contains flavonolignan Silymarin, which is an important bioactive principle having anticancer, antiinflamma...

Chemotherapeutic agent, busulfan, induce oxidative stress as a mechanism to kill cancer cells, however, it may also cause in non-target tissues and thereby lead normal tissue injury. Milk thistle (Silybum marianum L.) has been used for centuries herbal drug. The present study was carried out investigate the potential effects of wild Silybum seed ethanol extract (SMSEE) intervention on induced b...

objective: silybum marianum has been used for centuries in herbal medicine for treatment of liver diseases. currently, there is no data available on the possible effects of silymarin on fetal development. this study aimed to investigate the teratogenic effect of silymarin on balb/c mice fetuses. materials and methods: a total of 40 pregnant mice were divided into 4 groups of 10 mice each. three...

Many aldehydes are important components of natural flavours. They are used in food, cosmetic, and biomedical industries in large amounts. Plant cells or microorganisms carry out their production by biotransformation, which is one of the biotechnological methods that allow them to be defined as 'natural'. Cell cultures of Silybum marianum and Peganum harmala have been studied with a view to in...

background: cadmium has toxicological significance and there is no effective therapy for its poisoning. objective: the effects of silymarin on the parameters indicative of cadmium-induced toxicity were studied in rats. methods: 130 adult male wistar rats were divided into 13 groups each comprising 10 rats. 1 group as control group was not administered neither cadmium nor silymarin. cadmium chlo...