Introduction: Development of a novel radiopharmaceutical needs assessment of its biological- distribution in animal models, most commonly mice prior to its common application. This study describes the biodistribution and absorbed dose prediction 131I-MIBG in human organs after injection in mice.   Materials and Methods: In this research, 131I-MIBG radiopha...

OBJECTIVE This article presents a brief synopsis of the 1997 regulations from the Nuclear Regulatory Commission concerning the release from the hospital of patients treated for thyroid disease with 131I. A simplified checklist is provided to demonstrate the instructions to patients and the new conditions for release of patients containing a higher level of 131I radioactivity than was allowed un...

Delivery of targeted hematopoietic irradiation using radiolabeled monoclonal antibody may improve the outcome of marrow transplantation for advanced acute leukemia by decreasing relapse without increasing toxicity. We conducted a phase I study that examined the biodistribution of 131I-labeled anti-CD45 antibody and determined the toxicity of escalating doses of targeted radiation combined with ...

BACKGROUND Both tumor cells and their supporting endothelial cells should be considered for targeted cell killing when designing cancer treatments. Here we investigated the feasibility of combining radioiodide and antiangiogenic therapies after baculovirus-mediated transfer of genes encoding the sodium iodide symporter (NIS) and plasminogen kringle 5 (K5). METHODS A recombinant baculovirus co...

Objective Pheochromocytoma and paraganglioma (PPGLs) are rare neuroendocrine tumors derived from the adrenal medulla or extra-adrenal paraganglioma from extra-adrenal chromaffin tissue. Although malignant PPGLs has miserable prognosis, the treatment strategy remains to be established. An internal radiation therapy using [131I]meta-iodobenzylguanidine (131I-mIBG) called MIBG therapy has been att...

Childhood familial pheochromocytoma was investigated in four patients by abdominal computed tomographic scan, [131I]metaiodobenzylguanidine scan, and vena caval catecholamine sampling. Results conflicted with surgical findings. Computed tomographic scan identified all four adrenal tumors but missed two midline tumors in one patient. [131I]metaiodobenzylguanidine scan identified two of three adr...

Melanoma is a tumor of continuously increasing incidence for which new methods of imaging and targeted therapy are widely sought. Radioiodinated methylene blue is a promising tracer, showing selective uptake in human pigmented melanoma cells. We performed 131I-labeling of the tracer using 1% methylene blue injection United States Pharmacopeia (USP) and 131I sodium iodide. For quality control, a...

Thyroid stunning is usually defined as decreased uptake or trapping of radioiodine 131I by normal thyroid tissue or differentiated thyroid cancer after diagnostic administration of 131I. As simple as this definition might be, it is as important to understand the mechanisms by which this phenomenon, if real, is caused. There are 2 possible explanations: Stunning may result either from a reductio...