Endogenous cannabinoids (eCBs) are produced and mobilized in a cytosolic calcium ([Ca2+]i)-dependent manner, and they regulate excitatory and inhibitory neurotransmitter release by acting as retrograde messengers. An indirect but real-time bioassay for this process on GABAergic transmission is DSI (depolarization-induced suppression of inhibition). The magnitude of DSI correlates linearly with ...

BACKGROUND Hemodialysis patients have a high physical and psychosocial symptom burden. There is no valid and reliable tool for assessing symptoms of hemodialysis patients in Iran. OBJECTIVES The aim of this study was to determine psychometric properties of the Persian version of the dialysis symptom index (DSI). PATIENTS AND METHODS The forward-backward procedure was applied to translate th...

Basics The Dysphonia Severity Index (DSI) is designed as an objective and quantitative correlate of voice quality. It is based on a multivariate analysis of an extended database of more than 1000 normal and pathologic voices for the multi-center study trial initiated by the Belgian Study Group on Voice Disorders (Van de Heyning, et al., 1996). Per patient, more than 45 voice characteristics and...

The mechanisms by which dietary sodium modulates cardiovascular risk are not fully understood. This study investigated whether sodium intake is related to carotid structure and hemodynamics and to plasma matrix metalloproteinase (MMP) activity in hypertensive adults. One hundred thirty-four participants were cross-sectionally evaluated by clinical history, anthropometry, carotid ultrasound, and...

OBJECTIVE The present study aimed to validate a Korean version of the self-report Depressive Symptom Inventory-Suicidality Subscale (DSI-SS). METHODS 553 South Korean undergraduate students (aged 18-34 years, 74.8% females) completed questionnaires. Participants completed Korean versions of the self-report Depressive Symptom Inventory-Suicidality Subscale (DSI-SS), Beck Depression Inventory-I...

OBJECTIVE To assess independent prognostic factors described in the literature. Thus, to identify different risk groups. METHODS Review of the records with a diagnosis of primary vulvar squamous cell carcinoma (January/1992-January/2012). INCLUSION CRITERIA depth of stromal invasion (DSI) >1mm, pathological tumor size >2 cm, and pathological tumor-free margin ≥ 8 mm. Patients who underwent ...

BACKGROUND & AIMS We previously demonstrated that short-term oral administration of the probiotic Lactobacillus reuteri 6475 enhanced bone density in male but not female mice. We also established that L. reuteri 6475 enhanced bone health and prevented bone loss in estrogen-deficient female mice. In this study, we tested whether a mild inflammatory state and/or a long-term treatment with the pro...