The contribution of specific cell types to the production of cytokines that regulate hematopoiesis is still not well defined. We have previously identified T cell-dependent regulation of hematopoietic progenitor cell (HPC) numbers and cycling. In this report, we demonstrated that HPC activity is decreased in mice with STAT3-deficient T cells, a phenotype that is not because of decreased express...

Traditionally high-performance computing (HPC) systems have been optimized to support mostly monolithic workloads. The workload of many important scientific applications however, is comprised of spatially and temporally heterogeneous tasks that are often dynamically inter-related. These workloads can benefit from being executed at scale on HPC resources but a tension exists between their resour...

Key computational kernels must run near their peak efficiency for most high performance computing (HPC) applications. Getting this level of efficiency has always required extensive tuning of the kernel on a particular platform of interest. The success or failure of an optimization is usually measured by invoking a timer. Understanding how to build reliable and context-sensitive timers is one of...

In this article we describe the application of HPC standard benchmark tests to Amazon’s EC2 cloud computing system, in order to explore the utility of EC2 for modest HPC style applications. Based on these benchmarks we find that the EC2 cloud system is emerging as a credible solution for supporting responsive on-demand, small sized, HPC applications. We illustrate this point with a demonstratio...

T he idea of green high-performance computing (HPC) has been gaining traction over the past fi ve years. In November 2008, the Green 500 list (www.green500.org) was introduced to “raise awareness about power consumption, promote alternative total cost of ownership performance metrics, and ensure that supercomputers only simulate climate change and not create it.” The Green 500 lists the world’s...

Heterotrophic plate count (HPC) constitutes a common indicator for monitoring of microbiological water quality in distribution systems (DS). This paper aims to identify factors explaining the spatiotemporal distribution of heterotrophic bacteria and model their occurrence in the distribution system. The case under study is the DS of Quebec City, Canada. The study is based on a robust database r...

SIXTY SAMPLES OF TISSUE FRAGMENTS WITH LESIONS SUGGESTIVE OF TUBERCULOSIS FROM BOVINE ABATTOIRS, KEPT IN SATURATED SOLUTION OF SODIUM BORATE, WERE SUBJECTED TO FOUR TREATMENTS: 4% NaOH (Petroff Method), 12 % H2SO4 and 1.5% HPC (1-Hexadecylpyridinium Chloride) decontamination, and physiological saline solution (control). The HPC method showed the lowest contamination rate (3%) when compared to c...

In rheumatoid arthritis (RA), hematopoietic progenitor cells (HPC) have age-inappropriate telomeric shortening suggesting premature senescence and possible restriction of proliferative capacity. In response to hematopoietic growth factors RA-derived CD34(+) HPC expanded significantly less than age-matched controls. Cell surface receptors for stem cell factor (SCF), Flt 3-Ligand, IL-3 and IL-6 w...

This paper presents the Interval Categorizer Tessellationbased Model (ICTM) for the simultaneous categorization of geographic regions considering several characteristics (e.g., relief, vegetation, land use etc.). Interval techniques are used for the modelling of uncertain data and the control of discretization errors. HPC-ICTM is an implementation of the model for clusters. We analyze the perfo...

The HPC Challenge benchmark suite (HPCC) was released to analyze the performance of high-performance computing architectures using several kernels to measure different memory and hardware access patterns comprising latency based measurements, memory streaming, inter-process communication and floating point computation. HPCC defines a set of benchmarks augmenting the High Performance Linpack use...