Serum luteinizing hormone, follicle-stimulating hormone, prolactin, thyroid-stimulating hormone, and growth hormone and hypothalamic luliberin and thyroliberin contents were measured at given times of the estrous cycle in a dimethylbenz(a)anthracene (DMBA)-susceptible strain of rat (Sprague-Daw ley) and in a DMBA-resistant strain of rat (Wistar) for periods up to the appearance of the first mam...

7,12-Dimethylbenz[a]anthracene (7,12-DMBA) exerts adrenocorticolytic effects which set it apart from all other polynuclear aromatic hydrocarbons and aromatic amines which have been investigated. Adrenal damage by this compound appears to be due to its steric and electronic properties together with its unusually high solubility in lipides. Many compounds given prior to 7,12-DMBA induced protecti...

Serum luteinizing hormone, follicle-stimulating hormone, prolactin, thyroid-stimulating hormone, and growth hormone and hypothalamic luliberin and thyroliberin contents were measured at given times of the estrous cycle in a dimethylbenz(a)anthracene (DMBA)-susceptible strain of rat (Sprague-Daw ley) and in a DMBA-resistant strain of rat (Wistar) for periods up to the appearance of the first mam...

The effects of nonspecific stimulation of the reticuloendothelial system by Bacillus Calmette-Guérin(BCG) on rat mammary carcinogenesis were studied. A single feeding of dimethylbenz(a)anthracene (DMBA) to female Sprague-Dawley rats at the age of 50 days induced both an immediate depression of spleen weight and reduction of the number of mononuclear spleen cells and the formation of multiple m...

The purpose of our study was to determine the effect of the combined action of phytochemicals on the early stages of skin tumorigenesis, i.e. initiation and promotion. We tested calcium D-glucarate (CG) given in the diet, while resveratrol (RES) and ursolic acid (UA) were applied topically. The 7,12-dimethylbenz[a]anthracene (DMBA)-initiated, 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted ...

Female Sencar mice (6 weeks old) were administered 1 mg of 7,12-dimethylbenz[a]anthracene (DMBA) by oral gavage once a week for 5 weeks. At 20 weeks after the first dose of DMBA, 68% of mice developed mammary tumors (the average 1.08 tumors per mouse) and 45% had lymphomas/leukemias. Feeding 1% dibenzoylmethane (DBM) in AIN 76A diet, starting at 2 weeks before the first dose of DMBA and continu...

We have studied the effects of hypothyroidism on the induc tion phase and growth phase of mammary cancer induced in the rat by 7,12-dimethylbenz(a)anthracene (DMBA). Moderate hypothyroidism was initiated before administration of DMBA by treatment with propylthiouracil (PTU) (0.5 to 2.0 mg/100 ml), and PTU was continued for 4 days after DMBA. Four months later, the tumor incidence in this group,...

Female rats of ten different inbred strains were tested for their suscep tibility to 7, 12-dimethylbenz|a|anthracene (DMBA)-induced mammary adenocarcinogenesis. Five of these strains (OM. NSD, \VI. LEWIS, BUFF) were demonstrated to be highly susceptible to DMBA exposure developing >2 continuously growing, macroscopically detectable mam mary adenocarcinomas/rat following gastric intubation with ...