Repetitive sequences account for more than 50% of the human genome. Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant disease associated with reduction in the copy number of the D4Z4 repeat mapping to 4q35. By an unknown mechanism, D4Z4 deletion causes an epigenetic switch leading to de-repression of 4q35 genes. Here we show that the Polycomb group of epigenetic repressors ...

Based on the scientific literature, this paper emphasises destination brand experience (DBE) (multidimensional construct and second-order factor) in order to analyse implications it plays regarding visitors’ satisfaction, their intentions revisit recommend it. In terms of methodology, a confirmatory factor analysis was used test model research hypotheses. The sample composed 507 tourists who vi...

This article proposes a method to engineer degenerate band-edge conditions in periodic substrate-integrated waveguides (SIWs). A band edge (DBE) is fourth-order exceptional point originating from the coupling of four Floquet–Bloch modes; it leads dispersion relation flatter than regular (RBE) and suitable design slow wave structures high <inline-formula xmlns:mml="http://www.w3.org/1998/Math/Ma...

The purpose of the article is to explore faults that exist in laws governing appointment school principals schools South Africa. advances an argument there are numerous flaws regulate schools. will contribute revision and strengthening used principals. Some sections African Schools Act 9) SASA militate against good intentions Department Basic Education (DBE) have best suitable candidates appoin...

The Digital Business Ecosystem Integrated Project funded by the EU aims at the development of a Europe-Wide virtual economic environment where European SMEs will advertise themselves and their service offerings with the purpose of competing, collaborating and co-evolving with other SMEs. One of the main strategic goals for this project is to model, design and implement such an environment based...

As part of the construction of a Europe-wide Digital Business Ecosystem, in this paper we begin to ask several questions about how small and medium-sized enterprises (SMEs), their business processes, and the services they rely upon can be modelled. For the purposes of this paper we focus more on the subset of SMEs that can be loosely described as software producers. The Digital Business Ecosyst...

The integration of information and communications technology (ICT) into the education system has led to changes in way teaching learning are conducted. These have necessitated need for teachers ICT skills that would help them integrate (T&amp;L). Hence, this qualitative study was conducted investigate state readiness Engineering Graphics Design (EGD) T&amp;L uMgungundlovu secondary schools. Con...

We propose a new class of oscillators by engineering the dispersion two-coupled periodic waveguides to exhibit degenerate band edge (DBE). The DBE is an exceptional point degeneracy (EPD) order four, i.e., representing coalescence four eigenmodes waveguide system without loss and gain. present distributed oscillator realized in coupled transmission lines with unique mode selection scheme that l...

Abstract Digital business ecosystem (DBE) is a paradigm that enables developing and monitoring novel models of collaborating organisations individuals using ICT as the foundation. Different from traditional online networked such manufacturer, retailer, or franchise centred, shared digital environment, DBE fosters heterogeneity, symbiosis, coevolution, self-organisation its multiple actors, whic...

Cylindrical liquid storage tanks are considered as vital structures in industrial complex whose nonlinear dynamic behavior is of crucial importance. Some of these structures around the world have demonstrated poor seismic behavior over the last decades. There are several methods and techniques for rehabilitation and reducing damages in these structures which among them passive control devices, ...