Tropomyosin (TM) is a coiled-coil dimer of alpha-helical peptides, which self associates in a head- to-tail fashion along actin polymers, conferring stability to the microfilaments and serving a regulatory function in acto-myosin driven force generation. While the major amount of TM is associated with filaments also in non-muscle cells, it was recently reported that there are isoform-specific p...

The mechanical stimulation of the outer hair cell hair bundle (HB) is a key step in nonlinear cochlear amplification. We show how two-tone suppression (TTS), a hallmark of cochlear nonlinearity, can be used as an indirect measure of HB stimulation. Using two different nonlinear computational models of the cochlea, we investigate the effect of altering the mechanical load applied by the tectoria...

Purpose Abnormal accumulation of extracellular matrix (ECM) in the trabecular meshwork (TM) is associated with decreased aqueous humor outflow facility and IOP elevation in POAG. Previously, we have developed a transgenic mouse model of POAG (Tg-MYOCY437H) by expressing human mutant myocilin (MYOC), a known genetic cause of POAG. The purpose of this study is to examine whether expression of mut...

BACKGROUND Although rare, brain abnormalities without optic neuritis (ON) or transverse myelitis (TM) diagnosed with neuromyelitis optica spectrum disorder (NMOSD) have been reported in patients positive for the aquaporin-4 (AQP4) antibody. OBJECTIVE To analyze demographic and clinical differences among NMOSD patients without ON or TM, those with either ON or TM, and patients with simultaneou...

In this paper we generalize the well known construction of ”classic” measure theory to the fuzzy case. We consider such T-norm based classes of fuzzy sets as T-semirings and T-tribes (T sigmaalgebras), such fuzzy valued functions as elementary T-measures, exterior T-measures and T-measures, and we suggest the construction of a TM-measure by extension of an elementary TM-measure on a TM-semiring...

We prove that the Tutte polynomial of a coloopless paving matroid is convex along the portions of the line segments x + y = p lying in the positive quadrant. Every coloopless paving matroid is in the class of matroids which contain two disjoint bases or whose ground set is the union of two bases. For this latter class we give a proof that TM (a, a) ≤ max{TM (2a, 0), TM (0, 2a)} for a ≥ 2. We co...

AIM Public access defibrillation rarely reaches out-of-hospital cardiac arrest (OHCA) patients in residential areas. We developed a text message (TM) alert system, dispatching local lay rescuers (TM-responders). We analyzed the functioning of this system, focusing on response times and early defibrillation in relation to other responders. METHODS In July 2013, 14112 TM-responders and 1550 aut...

Magnetic susceptibility, specific heat, and muon spin relaxation ($\ensuremath{\mu}\mathrm{SR}$) measurements have been performed on a synthesized three-dimensional sandglass-type lattice ${\mathrm{Tm}}_{3}{\mathrm{SbO}}_{7}$, where two inequivalent sets of non-Kramers ${\mathrm{Tm}}^{3+}$ ions (${\mathrm{Tm}}_{1}^{3+}$ ${\mathrm{Tm}}_{2}^{3+})$ show crystal electrical field effect at different...