Thorough QT studies conducted according to the International Council on Harmonisation E14 guideline are required for new nonantiarrhythmic drugs to assess the potential to prolong ventricular repolarization. Special considerations may be needed for conducting such studies with antidiabetes drugs as changes in blood glucose and other physiologic parameters affected by antidiabetes drugs may prol...

BACKGROUND Many studies focusing on the effects of local anaesthetics on QT intervals have been performed, but the articles evaluating the relationship between thoracic epidural anaesthesia combined with general anaesthesia and QT parameters are very limited. AIMS We aimed to compare the effects of bupivacaine and ropivacaine on QT interval, corrected QT, dispersion of QT, and corrected dispe...

CONTEXT Of the several factors implicated in causing QT interval prolongation and torsades de pointes, errors in the use of medications that may prolong this interval deserve special attention. OBJECTIVE To systematically summarize the available clinical data on the QT interval and to offer improved recommendations for the use of QT-prolonging medications. DATA SOURCES We searched MEDLINE f...

BACKGROUND The risk of developing cardiovascular diseases is higher in patients on haemodialysis than in the general population. These patients may develop arrhythmias that depend on the extra- and intracellular concentrations of potassium. ECG findings, particularly the QT interval and its dispersion (QT(d)) and the QT(c) (QT interval corrected for heart rate according to Bazett's formula) and...

background: myocardial ischemia is one of several causes of prolonged qt dispersion. the aim of this study was to evaluate the effect that percutaneous coronary intervention has on the depolarization and repolarization parameters of surface electrocardiography in patients with chronic stable angina. methods: we assessed the effects of full revascularization in patients with chronic stable angin...

We address the problem of online change detection in multivariate datastreams, and we introduce QuantTree Exponentially Weighted Moving Average (QT-EWMA), a nonparametric change-detection algorithm that can control expected time before false alarm, yielding desired Run Length (ARL$_0$). Controlling alarms is crucial many applications rarely guaranteed by algorithms monitor datastreams without k...

Background: QT dispersion is the difference between the longest and the shortest QT intervals as measured from the 12 lead standard ECG. It reflects ventricular repolarisation heterogeneity which may lead to ventricular arrhythmias in certain cases. Myocardial ischemia plays a central role in the pathophysiology of prolonged QT dispersion leading to re-entrant type ventricular arrhythmias. Curr...

The n-dimensional cube Q is the graph whose vertices are the subsets of {1, . . . , n}, with two vertices adjacent if and only if their symmetric difference is a singleton. Clearly Q has diameter and radius n. Write M = n2n−1 = e(Q) for the size of Q. Let Q̃ = (Qt) M 0 be a random Q-process. Thus Qt is a spanning subgraph of Q n of size t, and Qt is obtained from Qt−1 by the random addition of a...

the relationship between qt dispersion and myocardial ischemia is still controversial. therefore, we aimed to investigate the relationship between qtd and the severity and extent of myocardial ischemia. in this cross-sectional study, 141 patients having symptoms of cad who referred to our medical center during 2009-2010, and were examined with myocardial isotope scan and ecg, were enrolled. bas...