The solubility enhancement of poorly soluble compounds is an important task in pharmaceutical technology as it leads to better bioavailability and a more efficient application. Fused dispersions (FDs) of simvastatin (SIM) using PEO-PPO block copolymer were prepared which paved the way for the formation of an amorphous product with enhanced dissolution and bioavailability. The accumulative solub...

BACKGROUND The medial ulnar collateral ligament (MUCL) is an important passive stabilizer to the valgus stresses that athletes experience during overhead throwing motion. However, the role of the flexor-pronator muscles as active stabilizers to valgus stress is not well defined in the literature. The objectives of this study were to quantify the relative contribution of the individual flexor-pr...

OBJECTIVE Compare the quality of life (QOL) of youth living with visible facial differences (FDs) with youth living with a visible nonfacial difference (i.e., mobility limitations), an invisible difference (i.e., attention deficit/hyperactivity disorder), or no known difference. DESIGN An observational study of perceived QOL among adolescents with FDs (n = 56), adolescents with no diagnosed c...

An interesting feature of the muscular organization of the human hand is that the main flexors and extensors of the fingers are compartmentalized and give rise to multiple parallel tendons that insert onto all the fingers. Previous studies of motor-unit synchrony in extensor digitorum and flexor digitorum profundus indicated that synaptic input to motor neurons supplying these multitendoned mus...

Risk factors for activity-related tendon disorders of the hand include applied force, duration, and rate of loading. Understanding the relationship between external loading conditions and internal tendon forces can elucidate their role in injury and rehabilitation. The goal of this investigation is to determine whether the rate of force applied at the fingertip affects in vivo forces in the fle...

An interesting feature of the muscular organization of the human hand is that the main flexors and extensors of the fingers are compartmentalized and give rise to multiple parallel tendons that insert onto all the fingers. Previous studies of motor unit synchrony in extensor digitorum (Keen and Fuglevand 2004b) and flexor digitorum profundus (Reilly et al. 2004; Winges and Santello 2004) have i...

molecular taxonomy based on the primary structures of common plant proteins, instead of so-called secondary metabolites. To evaluate the effectiveness of this concept, we carried out a series of studies on the family Solanaceae, using ferredoxin (Fd), an iron-sulfur electron-transfer protein. This protein was chosen for this study because it is easy to isolate and has an appropriate molecular w...

Cosmic ray (CR) diurnal anisotropy and Forbush decreases (FDs), as well the relationship between them, have received considerable study. Several astrophysicists focused on speculated impact of FDs amplitude CR variations different timescales. In an attempt to disentangle contribution FDs, days events are traditionally excluded while calculating in individual neutron monitor (NM) data. But impli...

Modern applications increasingly require the storage of data beyond relational structure. The challenge of providing well-founded data models that can handle complex objects such as lists, sets, multisets, unions and references has not been met yet in a completely satisfactory way. The success of such data models will greatly depend on the existence of automated database design techniques that ...