BACKGROUND AND AIMS We studied damage accrual and factors determining development and progression of damage in an international cohort of systemic lupus erythematosus (SLE) patients. METHODS The Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort recruited patients within 15 months of developing four or more 1997 American College of Rheumatology (ACR) criteria for SLE;...

Over the last ten years development of Spatial Data Infrastructures (SDIs) has become an important subject being a driving force towards the vision of Digital Earth increasing the availibility and accessibility of geographic information exchange and sharing of spatial data. Worldwide, large investments have been made to develop SDI initiatives. Given the expenditure and society‟s interest in th...

We present VLT/NACO SDI images of the very nearby star SCR 1845-6357 (hereafter SCR 1845). SCR 1845 is a recently discovered (Hambly et al. 2004) M8.5 star just 3.85 pc from the Sun (Henry et al. 2006). Using the capabilities of the unique SDI device, we discovered a substellar companion to SCR 1845 at a separation of 4.5 AU (1.170”±0.003” on the sky) and fainter by 3.57±0.057 mag in the 1.575 ...

Apoptosis was induced in immature and mature sperm in the presence or absence of poly (ADP-ribose) polymerase (PARP) inhibitor. The association of cleaved (cPARP) with sperm morphology was examined using sperm deformity index (SDI) score. The SDI scores are associated with PARP cleavage as an early marker of apoptosis.

The gazetteer is perceived differently in different contexts: Geographical Information Systems, Digital Libraries, Toponymic Standardization Processes and Cartotoponomy. These contexts shape the content of the SDI gazetteer. This paper analyzes the conventional core properties and the nature of the gazetteer to ease the building of SDI gazetteers.

On a decision-making instrument known as the "gambling task" (GT), a subgroup of substance dependent individuals (SDI) opted for choices that yield high immediate gains in spite of higher future losses. This resembles the behavior of patients with ventromedial (VM) prefrontal cortex lesions. In this study, we addressed the possibility that hypersensitivity to reward may account for the "myopia"...

BACKGROUND Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) and anaplastic lymphoma kinase (ALK) inhibitors have dramatically changed the strategy of medical treatment of lung cancer. Patients should be screened for the presence of the EGFR mutation or echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion gene prior to chemotherapy to predict their clinical r...

AIMS The relationship between temporal changes in left ventricular (LV) dyssynchrony and LV functional recovery after acute myocardial infarction (MI) remains unclear. Accordingly, the aim of the present study was to evaluate the temporal evolution of LV synchronicity after acute MI, and to explore the relationship between changes in LV systolic function and LV synchronicity. METHODS AND RESU...

BACKGROUND Information obtained from vehicle crash scenes, called kinematics, may prove useful in the management of victims and may complement anatomical and physiological findings. OBJECTIVES In addition to analyzing the significance of age, gender, position occupied in the vehicle, the use of restraint systems, and ejection from the vehicle, the objective was to carry out a preliminary stud...