BACKGROUND Axon migrations are guided by extracellular cues that can act as repellants or attractants. However, the logic underlying the manner through which attractive and repulsive responses are determined is unclear. Many extracellular guidance cues, and the cellular components that mediate their signals, have been implicated in both types of responses. RESULTS Genetic analyses indicate th...

Recent work has implicated the actin cytoskeleton in tissue size control and tumourigenesis, but how changes in actin dynamics contribute to hyperplastic growth is still unclear. Overexpression of Pico, the only Drosophila Mig-10/RIAM/Lamellipodin adapter protein family member, has been linked to tissue overgrowth via its effect on the myocardin-related transcription factor (Mrtf), an F-actin s...

The practice of environmental impact assessment (EIA) in the planning processes of infrastructure projects has created significant awareness in many parts of the world on the benefits of environmentally sound and sustainable urban development. In the Philippines, the construction of structural flood mitigation measures (SFMMs) gets high priority from the national government to immediately addre...

The current situation of world’s environmental issues, indicates that not only the man-made environmental damages have not been diminished, but also has given rise to more acute issues such as water and soil pollution, biodiversity loss, ozone depletion, greenhouse phenomena, etc. One of the most prominent effects of urban development on environmental problems caused by solid waste generated in...

An increased risk of myocardial ischemic changes was demonstrated in patients suffering from panic disorder (PD). Using classical ECG methods, this risk cannot be evaluated in most patients. We measured the vectocardiogram (VCG) using Frank orthogonal leads and body surface maps (BSM) including 12-lead ECG. In our study of 11 PD patients (2 men, 9 women), without any seizures and pharmacologica...

Grb14, a member of the Grb7-10-14 family of cytoplasmic adaptor proteins, is a tissue-specific negative regulator of insulin signaling. Grb7-10-14 contain several signaling modules, including a Ras-associating (RA) domain, a pleckstrin-homology (PH) domain, a family-specific BPS (between PH and SH2) region, and a C-terminal Src-homology-2 (SH2) domain. We showed previously that the RA and PH do...