Trigonella foenum (TF) has long been used in the traditional Indian systems of medicine for the treatment of various ailments. The objective was to study the anabolic and androgenic activity of the furostanol glycosides fraction of Trigonella foenum-graecum (Fenu-FG) in immature castrated male Wistar rats. It was also aimed to investigate the effect of Fenu-FG on testicular histology in non-cas...

BACKGROUND To evaluate the effect of nucleotide P2Y(2) receptor agonists INS542 and uridine 5'-triphosphate (UTP) on the outward active transport of fluorescein across rabbit blood-retina barrier (BRB) in vivo. METHODS Injection (0.1 ml) of INS542 (0.1 or 1mM), phosphate buffered solution, or UTP (1 or 10mM) was made in Dutch-belted rabbits. Differential vitreous fluorophotometry (DVF) was pe...

The phenylalanine-glycine-repeat nucleoporins (FG-Nups), which occupy the lumen of the nuclear pore complex (NPC), are critical for transport between the nucleus and cytosol. Although NPCs differ in composition across species, they are largely conserved in organization and function. Transport through the pore is on the millisecond timescale. Here, to explore the dynamics of nucleoporins on this...

The surface-localized M protein of Streptococcus pyogenes is a major virulence factor that inhibits phagocytosis, as determined ex vivo. Because little is known about the role of M protein in vivo we analyzed the contribution of different M protein regions to virulence, using the fibrinogen (Fg)-binding M5 protein and a mouse model of acute invasive infection. This model was suitable, because M...

Background: The purpose of this study was to review key differences between necrotizing soft tissue infections (NSTI) and Fournier’s Gangrene (FG) in demographics, comorbidities, laboratory findings, cost, and clinical course. Methods: The burn registry of a Level 1 trauma and burn center in Lubbock, Texas was used to identify and retrospectively review medical records of patients with NSTIs an...

Identifying the neural underpinnings of socio-emotional deficits in 22q11.2 deletion syndrome (22q11DS) may elucidate recurrent psychosis in affected individuals. In the current study, we investigate volumetric changes in 22q11DS to the fusiform gyrus (FG), a region associated with hypoactivity during fMRI, by manually tracing the FG in 42 individuals with 22q11DS and 54 healthy controls. Large...

The 3-Colouring of a graph is a classic NP-complete problem. We show that some solutions for the 3-Colouring can be built in polynomial time based on the number of basic cycles existing in the graph. For this, we design a reduction from proper 3-Colouring of a graph G to a 2-CF Boolean formula FG, where the number of clauses in FG depends on the number of basic cycles in G. Any model of FG prov...

Nuclear pore proteins with phenylalanine-glycine repeats are vital to the functional transport of molecules across the nuclear pore complex. The current study investigates the binding of these FG-nucleoporins to the Cse1p:Kap60p:RanGTP nuclear export complex. Fourteen binding spots for FG-nucleoporin peptides are revealed on the surface of Cse1p, and 5 are revealed on the Kap60p surface. Taken ...

this study investigates natural frequency analysis of an fg composite rectangular plate partially contacting with a bounded fluid. the material properties are assumed to be varying continuously through the thickness direction according to a simple power law distribution in terms of volume fraction of material constituents. wet dynamic transverse displacements of the plate are approximated by a ...