We discuss ideas for using the Higher-Order Logic (HOL) theorem-proving system as an infrastructure for programs that reference or carry proofs of their correctness. Such programs, which we call Proof-Referencing Code (PRC), could be useful or even essential for applications where security of mobile code is important, but where authentication is impractical and runtime checking is expensive. We...

KRAS is an attractive pancreatic ductal adenocarcinoma (PDAC) therapeutic target. E3 ligase is thought to be the component of the ubiquitin conjugation system that is directly responsible for substrate recognition. In this study, an engineered E3 ubiquitin ligase (RC-U) was generated to target the KRAS oncoprotein for ubiquitination and degradation. The engineered E3 ubiquitin ligases (RC-U) we...

measure of total energy loss because of the radiofrequency transmission line method used in the design of the instrument.5 Of the total energy loss, we can correct for bulk tissue loss between transducer and lung surface, transducer filtering, and radiation filtering between transducer and lung surface. The instantaneous PRC was computed pulse by pulse. The PRC used for clinical study is the me...

The phase-resetting curve (PRC) of a neural oscillator describes the effect of a perturbation on its periodic motion and is therefore useful to study how the neuron responds to stimuli and whether it phase locks to other neurons in a network. Combining theory, computer simulations and electrophysiological experiments we present a simple method for estimating the PRC of real neurons. This allows...

Cerebrovascular disease (CBVD) is very common in the People's Republic of China (PRC). In 8 of 12 large cities in the PRC, CBVD ranked first in frequency as a cause of death. The ratio of aneurysms to arteriovenous malformations (AVMs) was 0.84-2:1, much lower than in the United States (6.5:1). Hypertensive intracerebral hemorrhage (HIH) is the commonest cause of mortality in patients with CBVD...

Recommendation of related articles is an important feature of the PubMed. The PubMed Related Citations (PRC) algorithm is the engine that enables this feature, and it leverages information on 22 million citations. We analyzed the performance of the PRC algorithm on 4584 annotated articles from the 2005 Text REtrieval Conference (TREC) Genomics Track data. Our analysis indicated that the PRC hig...

Arthrodesis of the wrist has been considered as the gold standard for osteoarthritis of the wrist. In 1984 Watson and Ballet identified a specific pattern of carpal collapse (scapholunate advanced collapse = SLAC) with progressive osteoarthritis. In order to preserve some motion, other alternative procedures have been proposed: proximal row carpectomy (PRC) and scaphoidectomy combined with a fo...