نتایج جستجو برای: مدل cart

تعداد نتایج: 126680  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1993
G Q Zhao X Zhou H Eberspaecher M Solursh B de Crombrugghe

We identified a rat cDNA that encodes cartilage homeoprotein 1 (Cart-1). The deduced amino acid sequence of Cart-1 contains a paired-type homeodomain. Northern blot hybridization and RNase protection assay revealed that Cart-1 RNA was present at high levels in a well-differentiated rat chondrosarcoma tumor and in a cell line derived from this tumor. Cart-1 RNA was detected in primary mouse and ...

Journal: :Cell reports 2016
Ratna Chaturvedi Zhuo Luan Peiyi Guo Hong-Sheng Li

Recycling of neurotransmitters is essential for sustained neuronal signaling, yet recycling pathways for various transmitters, including histamine, remain poorly understood. In the first visual ganglion (lamina) of Drosophila, photoreceptor-released histamine is taken up into perisynaptic glia, converted to carcinine, and delivered back to the photoreceptor for histamine regeneration. Here, we ...

Journal: :The Journal of infectious diseases 2013
Gema Méndez-Lagares M Concepción Romero-Sánchez Ezequiel Ruiz-Mateos Miguel Genebat Sara Ferrando-Martínez María Á Muñoz-Fernández Yolanda M Pacheco Manuel Leal

Levels of soluble CD14 (sCD14) were longitudinally measured in 85 human immunodeficiency virus (HIV)-infected subjects during long-term receipt of suppressive combined antiretroviral therapy (cART) and compared to those in young and elderly HIV-negative control subjects. cART did not normalize sCD14 levels; rather, the HIV-infected group displayed a significantly higher sCD14 level at baseline ...

2012
Maude Loignon Hélène Brodeur Sonia Deschênes Denis Phaneuf Pangala V Bhat Emil Toma

BACKGROUND Several lines of evidence suggest that retinoids (retinol-ROL or vitamin A, and its active metabolites, retinoic acids-RAs) play important pathogenic roles in HIV infection and combination antiretroviral therapy (cART)-related events. We previously reported that antiretrovirals alter RAs synthesis in vitro. We hypothesised that in vivo serum retinoid concentrations are affected by bo...

2010
Adrian Schmid Sara Gianella Viktor von Wyl Karin J. Metzner Alexandra U. Scherrer Barbara Niederöst Claudia F. Althaus Philip Rieder Christina Grube Beda Joos Rainer Weber Marek Fischer Huldrych F. Günthard

BACKGROUND Although combination antiretroviral therapy (cART) initiated in the acute phase of HIV-1 infection may prevent expansion of the latent reservoir, its benefits remain controversial. In the current study, HIV-1 RNA transcription patterns in peripheral blood mononuclear cells (PBMC) were monitored during acute cART to assess the effect of early treatment on cellular viral reservoirs. ...

2016
Margaret McManus Eric Mick Richard Hudson Lynne M. Mofenson John L. Sullivan Mohan Somasundaran Katherine Luzuriaga

The primary aim of this study was to measure HIV-1 persistence following combination antiretroviral therapy (cART) in infants and children. Peripheral blood mononuclear cell (PBMC) HIV-1 DNA was quantified prior to and after 1 year of cART in 30 children, stratified by time of initiation (early, age <3 months, ET; late, age >3 months-2 years, LT). Pre-therapy PBMC HIV-1 DNA levels correlated wi...

Journal: :Current opinion in HIV and AIDS 2014
Alvaro H Borges Robert Dubrow Michael J Silverberg

PURPOSE OF REVIEW To critically appraise recent published literature about factors associated with cancer risk likely to be influenced by combination antiretroviral therapy (cART) in HIV-infected individuals, and the potential of earlier cART initiation to reduce this risk. RECENT FINDINGS Factors leading to increased risk of non-AIDS-defining malignancies (NADMs) in particular remain poorly ...

2012
Peizhong Mao Charles K. Meshul Philippe Thuillier Natalie R. S. Goldberg P. Hemachandra Reddy

The multifunctional neuropeptide Cocaine and Amphetamine Regulated Transcript (CART) is secreted from hypothalamus, pituitary, adrenal gland and pancreas. It also can be found in circulatory system. This feature suggests a general role for CART in different cells. In the present study, we demonstrate that CART protects mitochondrial DNA (mtDNA), cellular proteins and lipids against the oxidativ...

2014
Lore Claessens Anna Voce Stephen Knight Benn Sartorius Ashraf Coovadia

BACKGROUND Combination antiretroviral therapy (cART) is the current strategy to prevent mother-to-child transmission (PMTCT) of HIV. Women initiated on cART should continue taking treatment life-long or stop after cessation of breastfeeding depending on their CD4 cell count or on their World Health Organization (WHO) staging. Keeping people living with HIV on treatment is essential for the succ...

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