X chromosome dosage compensation in Drosophila requires chromosome-wide coordination of gene activation. The male-specific-lethal dosage compensation complex (DCC) identifies X chromosomal High Affinity Sites (HAS) from which it boosts transcription. A sub-class of HAS, PionX sites, represent first contacts on the X. Here, we explored the chromosomal interactions of representative PionX sites b...

[1] We use five years of data from the Atmospheric Infrared Sounder (AIRS) to develop a correlation between the frequency of Deep Convective Clouds (DCC) and the zonal mean tropical surface temperature. AIRS data show that the frequency of DCC in the tropical oceans is very temperature sensitive, increasing 45% per 1 K increase of the zonal mean surface temperature. The combination of the sensi...

The guidance of developing axons in the nervous system is mediated partly by diffusible chemoattractants secreted by axonal target cells. Netrins are chemoattractants for commissural axons in the vertebrate spinal cord, but the mechanisms through which they produce their effects are unknown. We show that Deleted in Colorectal Cancer (DCC), a transmembrane protein of the immunoglobulin superfami...

Loss ofheterozygosity (LOH) on chromosome 18q21 is found frequently in various human cancers. Three candidate tumor suppressor genes, DCC (de leted in colorectal carcinomas), DM24 (deleted in pancreatic carcinomas, locus 4), and MADR2/JV18-1(MAD-relatedgene2), have been doned and Identified from this chromosome region. We have reported recently that LOH on chromosome 18q is observed frequently ...

Background: Cell migration plays a key role in tumor invasion and metastasis. Deleted in colorectal cancer (DCC) and the unc5 homologues are receptors for secreted netrins that regulate cell and axon migration, cell adhesion, and tissue morphogenesis. Altered netrin and netrin receptor expression has been reported in aggressive tumors, including glioblastoma. Here, we investigated the involveme...

The mesocorticolimbic dopamine (DA) system is implicated in neurodevelopmental psychiatric disorders including schizophrenia but it is unknown how disruptions in brain development modify this system and increase predisposition to cognitive and behavioural abnormalities in adulthood. Netrins are guidance cues involved in the proper organization of neuronal connectivity during development. We hav...

BACKGROUND AND AIMS Genetic alterations of p53, K-ras and DCC genes have a pivotal role in the colorectal cancer progression. The aim of this study was to clarify the association between K-ras mutations, p53 aberrations and DCC loss of heterozygosity (LOH), with the patient outcome and tumor characteristics in 43 stage I-II colorectal cancer patients. METHODS Mutations in exons 5-8 of the p53...

OBJECTIVE. This study compared the effects of immediate (ICC) and delayed (DCC) cord clamping on very low birth weight (VLBW) infants on 2 primary variables: bronchopulmonary dysplasia (BPD) and suspected necrotizing enterocolitis (SNEC). Other outcome variables were late-onset sepsis (LOS) and intraventricular hemorrhage (IVH). STUDY DESIGN. This was a randomized, controlled unmasked trial in ...

In this study, we measured in vitro proliferative responses of peripheral blood mononuclear cells from both leprosy patients across the clinical spectrum and also healthy contacts from a leprosy-endemic population to delipidified cell components of Mycobacterium leprae (DCC) and Dharmendra lepromin. Dharmendra lepromin was poor in inducing in vitro T cell proliferation in all the study groups, ...

A DLL(Delay Locked Loop) with DCC(Duty Cycle Correction) has become an essential block in high speed memory and digital circuits. An SMD(Synchronous Mirror Delay) structure is widely used both for skew reduction and for DCC. In this paper, an area-efficient DLL structure based on the merged dual SMD is proposed. The merged structure allows the forward delay array to be shared between the DLL an...