OBJECTIVE To evaluate the role of complement factor C5 in a model of zymosan-induced multiple organ dysfunction syndrome. DESIGN Experimental animal study. SETTING Central animal laboratory of a university hospital. SUBJECTS Twenty-five C5-deficient B2D10/Old and 25 C5-sufficient B2D10/New mice. INTERVENTIONS On day 0, all mice received an intraperitoneal injection with zymosan suspende...

Candida albicans is an opportunistic pathogen that causes acute disseminated infections in immunocompromised hosts, representing an important cause of morbidity and mortality in these patients. To study the genetic control of susceptibility to disseminated C. albicans in mice, we phenotyped a group of 23 phylogenetically distant inbred strains for susceptibility to infection as measured by exte...

Transepithelial migration of neutrophils (PMN) is a defining characteristic of active inflammatory states of mucosal surfaces. The process of PMN transepithelial migration, while dependent on the neutrophil beta 2 integrin CD11b/CD18, remains poorly understood. In these studies, we define a monoclonal antibody, C5/D5, raised against epithelial membrane preparations, which markedly inhibits PMN ...

Due to its high greenhouse effect, the use of SF6 as main insulating gas is restricted in electric power field. Along with aim environmental protection, search for new alternative gases a lower effect and higher insulation strength has received lot attention. The properties have vital impact on performance medium-voltage distribution equipment. Firstly, based existing liquefaction temperatures ...

ABSTRACT: Cervical arthroplasty with disc prosthesis has been proposed as a treatment option for dogs Spondylomyelopathy. The present study developed novel vertebral dogs. Sixteen Functional Spinal Units (C5-C6) were collected from dog cadavers body weights ranging between 25 and 35 kg, their measurements used to design prosthetic disc. sizing of the was performed based on averages width, heigh...