BACKGROUND Angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARB) have been shown to delay the progression to proteinuria and kidney failure in hypertensive type 2 diabetic patients with diabetic nephropathy. Further synergistic effect may be obtained by combined therapy with both ARB and ACE inhibitors. OBJECTIVE To evaluate the effect of dual blockage of th...

Both angiotensin-receptor blockers (ARB) and angiotensin-converting enzyme inhibitors (ACEI) have protective effects against atrial fibrillation (AF). The differences between ARB and ACEI in their effects on the primary prevention of AF remain unclear. This study compared ARB and ACEI in combined antihypertensive medications for reducing the risk of AF in patients with hypertension, and determi...

The OSCAR study was a multicenter, prospective randomized open-label blinded end-point study of 1164 Japanese elderly hypertensive patients comparing the efficacy of angiotensin II receptor blocker (ARB) uptitration to an ARB plus calcium channel blocker (CCB) combination. In this prospective study, we performed prespecified subgroup analysis according to baseline estimated glomerular filtratio...

BACKGROUND A previous meta-analysis of randomized controlled studies that were not designed to investigate cancer as a primary outcome suggested that ARB-based therapy is associated with increased risk of cancer; however, results of recent observational studies considering the association have been contradictory. This study sought to evaluate the association between angiotensin receptor blocker...

in this study, al/al2o3 composites with two different particle sizes of 1 µm and 0.3 µm were produced via accumulative roll bonding (arb). the microstructure evolution, mechanical properties and fracture behavior of the composites were investigated. results show that higher arb cycles are required to achieve a uniform distribution of particles in the composite with 0.3 µm particle size. during ...

in this research, al-ni particle composite strips are formed by accumulative roll bonding (arb) process using al strips and ni powder. the rule of arb cycles and volume percentage (vol%) of ni powder on the microstructure, wear resistance and mechanical properties of the formed composites are investigated. according to the tensile test results, the yield stress and tensile strengths of the al -...

background: human exposure to antibiotic resistant bacteria (arb) is a public health concern which could occur in a number of ways. wastewaters seem to play an important role in the dissemination of bacteria and antibiotic resistant genes (args) in our environment. the aim of this study was to evaluate the occurrence of three groups of arb and their resistance genes in hospital and municipal wa...

The combination of angiotensin receptor blockers (ARB) and a thiazide diuretic (hereafter, ARB/diuretic) is expected to improve patient adherence and increase the therapeutic effects because of the lower number of pills that require to be administered. In addition, an ARB/diuretic combination alleviates hypokalemia that frequently develops in patients receiving thiazide diuretics. In this study...

BACKGROUND Many patients continue to have high blood pressure (BP) even after treatment with high-dose (H)-angiotensin II type 1 receptor blocker (ARB)/calcium channel blocker (CCB) or middle-dose (M)-ARB/CCB/hydrochlorothiazide (HCTZ). METHODS Thirty-two hypertensive patients who had the use of H-ARB/CCB or M-ARB/CCB/HCTZ were enrolled in this study. We applied a changeover with a switch to ...