INTRODUCTION Hypoparathyroidism might cause various musculoskeletal findings, resembling Spondyloarthropathies. CASE PRESENTATION We described a 52-year-old woman, diagnosed as a case of undifferentiated spondyloarthropathy for ten years, who was unresponsive to classic anti-inflammatory therapies. She developed anterior ischemic optic neuropathy and had elevated muscle enzymes during the cou...

Kearns-Sayre syndrome is a mitochondrial myopathy, which was first described by Tomas Kearn in 1958. Diagnostic symptoms of this condition include retinitis pigmentosa, chronic progressive external ophthalmoplegia, and one or more of the following factors: cardiac conduction system diseases, cerebellar ataxia, and cerebrospinal fluid (CSF) with protein content above 100 mg/dL. The nature of thi...

The etiology and pathophysiology of takotsubo cardiomyopathy have not yet been fully clarified. We report a case of takotsubo cardiomyopathy associated with severe hypocalcemia secondary to hypoparathyroidism. A 69-year-old woman presented with acute pulmonary edema caused by severe left ventricular dysfunction with apical ballooning compatible with takotsubo cardiomyopathy. Laboratory tests re...

Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a genetic syndrome that may present with hypocalcemia due to primary hypoparathyroidism (PH) at any age. We report a new diagnosis of 22q11.2DS in a 57-year-old man who presented with symptomatic hypocalcemia. It is important to consider genetic causes of hypocalcemia due to PH regardless of age. Learning points It is important to discard ge...

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome is a monogenic disorder associated with autoimmune destruction of both endocrine and nonendocrine tissues. The classic triad includes candidiasis, hypoparathyroidism, and Addison disease. Up to 25% of patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome also have gastrointestinal manifestati...

• Vol 10 • December 2008 Massive Brain Calcifications in APECED Brain calcifications are not rare in hypoparathyroidism or pseudohypoparathyroidism. Massive brain calcifications were found in brain computed tomography scans performed after an episode of pre-syncope in an Iranian Jewish woman known to have hypoparathyroidism and hypothyroidism. We present the case and briefly discuss recent prog...

The chromosome 22q11 deletion syndrome, which is synonymous with DiGeorge syndrome, is a congenital anomaly characterized by abnormal facies, congenital heart defects, hypoparathyroidism with hypocalcemia, and immunodeficiency. Neurological manifestations of the chromosome 22q11 deletion syndrome are variable, and include mental deficiency, speech disturbances, learning difficulties, attention ...

It is unusual for hypoparathyroidism and steatorrhoea to occur together. In steatorrhoea the plasma phosphorus is often low and the serum calcium either low or normal (Salvesen and Bee, 1953). Rarely there is marked elevation of the plasma phosphorus, denoting failure of parathyroid function, and symptoms of severe hypocalcaemia dominate the clinical picture. The cases illustrating this associa...

Commoncauses of magnesium (Mg) deficiency are small bowel diseases, such as chronic bowel disease, or resection of the small bowel. Chronic alcoholism is also an important cause of Mg deficiency. Clinical features and the degree of Mg deficiency appear to vary depending upon the underlying disorder as well as the portion and extensiveness of the small bowel disease. One of the most prominent ma...

Pamidronate is an effective drug used not only in patients with tumor-associated hypercalcemia, but also in normocalcemic patients with metastatic bone disease to relieve pains. We describe a 39-year-old normocalcemic patient with subclinical hypoparathyroidism and bone metastasis due to breast carcinoma. Following parenteral administration of 60 mg pamidronate, the corrected serum level of cal...