The use of synthetic peptides as HIV-1 inhibitors has been subject to research over recent years. Although the initial therapeutic attempts focused on HIV-coded enzymes, structural HIV proteins and, more specifically, the mechanisms that the virus uses to infect and replicate are now also considered therapeutic targets. The interest for viral fusion and entry inhibitors is growing significantly...

We give some constructions of diierential Gerstenhaber-Batalin-Vilkovisky algebras from a class of Lie algebras. In our construction, we make use of the solutions to the classical Yang-Baxter equations, and ideas from Poisson geometry. A graded commutative algebra (A; ^) with a bracket ] of degree?1 is called a G-algebra (Gerstenhaber algebra) if: (a) (A1]; ]) is a Lie algebra, where A1] is A w...

In Canada, diverse people face violence and abuse at alarming rates as a result of their gender, perceived or gender expression. This phenomenon is referred to gender-based (GBV). Gender-based has many manifestations, including sexual assault, femicide, intimate partner (IPV), well dowry-related violence, early forced marriage pregnancy, female genital mutilation, elder abuse, human trafficking...

aim : the aim of this study was to investigate the prevalence of gbv-c among iranian hbv positive patients using pcr-rflp technique. background : gbv-c was a member of flaviviridae family and recently propose to classify as members of a fourth genus in this family, named pegivirus  and suggest that at least one quarter of the world's population has been infected with this virus. gbv-c can be tr...

Gender based violence (GBV) is a heinous crime that Pakistani society facing. To deal with this menace, both the government and non-governmental organizations have taken steps at various levels to improve police service delivery, competence-building awareness-raising on GBV, establish women’s shelters, development welfare units in district departments, open helplines. However, these initiatives...

BACKGROUND GBV-C infection is associated with prolonged survival in HIV-infected people and GBV-C inhibits HIV replication in co-infection models. Expression of the GBV-C nonstructural phosphoprotein 5A (NS5A) decreases surface levels of the HIV co-receptor CXCR4, induces the release of SDF-1 and inhibits HIV replication in Jurkat CD4+ T cell lines. METHODOLOGY/PRINCIPAL FINDINGS Jurkat cell ...

To study the existence of GB virus C/hepatitis G virus (GBV-C/HGV) variants with different tropism, we have analyzed the heterogeneity and quasispecies composition of GBV-C/HGV isolated from in vitro-infected peripheral blood mononuclear cells (PBMC) and from sera, livers, and PBMC from two chronically infected patients. For this purpose, the GBV-C/HGV 5' noncoding region (5'NCR) was amplified ...

Gender based violence (GBV) is a preventable and serious human rights violation whereby an individual harmed on their gender. 1 The can be perpetrated physically, sexually, mentally or financially. This includes domestic violence, rape, feticide/infanticide female genital mutilation. As to expected, victims of GBV often suffer from life-long consequences at times even death.

Humanitarian and public institutions are increasingly relying on data from social media sites to measure public attitude, and provide timely public engagement. Such engagement supports the exploration of public views on important social issues such as gender-based violence (GBV). In this study, we examine Big (Social) Data consisting of nearly fourteen million tweets collected from the Twitter ...

Viral infections alter host cell homeostasis and this may lead to immune evasion and/or interfere with the replication of other microbes in coinfected hosts. Two flaviviruses are associated with a reduction in HIV replication or improved survival in HIV-infected people (dengue virus (DV) and GB virus type C (GBV-C)). GBV-C infection and expression of the GBV-C nonstructural protein 5A (NS5A) an...