Backgrounds and Aims: P53 gene is regarded important in pathogenesis of different cancers. Therefore, this study aimed to investigate the frequency of p53 gene codon 72 Arg/Pro polymorphism in women suffering from breast cancer. Materials and Methods: A total of 90 patients with breast cancer and 83 matched healthy control women participated in this case-control study. Genomic DNA was extrac...

The goal of this study was to clarify the role p16INK4a, p14ARF, and p53 protein expressions in carcinogenesis squamous cell carcinomas lip. p53, p14ARF proteins were examined 46 formaline-fixed paraffin embedded tissue specimens, which included 19 cases carcinoma lip, 14 actinic cheilitis, 13 normal mucosa. Immunoreactivity peritumoral epithelium adjacent als

: Wilms tumor (WT) is the most frequent renal of childhood and a highly responsive to chemotherapy. P53 ki67 are two important markers that have been evaluated in many cancers. The role p53 pathogenesis progression WT only partly understood. Over past decade, importance Ki-67

Background:Non-Melanoma Skin Cancer (NMSC), the most prevalent types being Squamous Cell Carcinoma (SCC) and Basal Cell Carcinoma (BCC), is the most common type of malignancy in human beings. These neoplasms are more frequent in the elderly and fair skinned people and mainly occur on sun-exposed sites of the body. Ultraviolet B (UVB) has a wel...

background : basal cell carcinoma is the most common form of skin cancer in men. increased marker expressions of apoptosis and cell proliferation have been found in the majority of basal cell carcinomas. our purpose was to determine whether any correlation between immunohistochemical expressions of p53 and ki-67 in different histopathological variants of basal cell carcinoma and patient’s age, ...

abstract introduction. p53 has been known as a tumor suppressor gene and also ki-67 is a cell cycle regulator. the aim of present study was to investigate p53 and ki-67 protein expression in the epithelial lining of odontogenic cysts and its correlation with their biologic behavior and the degree of inflammation within the cyst wall. methods. p53 and ki-67 immunoreactivity in 58 odontogenic cys...

the current challenges in the management of esophageal cancer are to obtain a better understanding of underlying molecular alterations to provide new treatment options. we studied the p53 and bcl-2 protein expression in esophageal carcinomas to correlate molecular alterations with clinicopathological findings. tissue samples of 37 patients with advanced esophageal carcinoma were analyzed by imm...

objective mustard gas (mg) is a poisoning chemical, mutagenic and carcinogenic alkylating agent. it is used during world war i and also iran-iraq conflict. the p53 tumor suppressor gene is involved in the pathogenesis of malignant disease. the aim of this study is to determine possible mutation in p53 gene of lung sample from mustard gas exposed patients. material and methods twelve lung biopsy...