Non-myeloablative allogeneic transplant (NMAT) has a curative potential for patients who are not myeloablative allogeneic transplant (MAT) candidates. We report a phase II trial of a NMAT regimen with cyclophosphamide and fludarabine in 40 patients; 21 of whom had a prior MAT. Day +100 and 1-year transplant-related mortality (TRM) post-NMAT were 13% and 34%, respectively. Day +100 and 1-year Ov...

Cet article porte sur le mCtabolisme de 1’Cnergie et l’utilisation des substrats dans la sous-alimentation. I1 s’intkresse particulikrement aux Ctudes sur l’homme, bien que des Ctudes sur l’animal soient Cgalement prises en compte, avec des distinctions entre le jeiine aigu (jusqu’h 4 jours), des pCriodes plus longues de sous-alimentation et la dCficience chronique en Cnergie (comme dans la sou...

This paper proposes a simplified design approach to predict the flexural behavior of reinforced concrete (RC) beams strengthened by high-performance textile mortar (TRM) under cyclic loads. Based on experimental results, effect main factors as well effectiveness and reliability TRM strengthening layer loads were examined per ACI 437 method. The reinforcement ratio original RC beams, layer, inte...

the aim of this study was to assess the predictive effect of the ebmt risk score on the outcomes of allogeneic stem cell transplantation in a relatively homogenous group of acute myelogenous leukemia (aml) patients regarding the occurrence of acute and chronic graft versus host disease (gvhd). this historical cohort study included adult patients (≥ 15 years old) with aml (n=363) who received al...

More than 240 million people worldwide are chronically infected with the hepatitis B virus (HBV) and are at risk of developing liver cirrhosis and hepatocellular carcinoma. HBV is a small, circular DNA virus that forms a mini-chromosome as its transcriptional template within the nucleus of hepatocytes. Therefore, HBV replication can be suppressed but the virus cannot be eliminated by nucleoside...

More than 240 million people worldwide are chronically infected with the hepatitis B virus (HBV) and are at risk of developing liver cirrhosis and hepatocellular carcinoma. HBV is a small, circular DNA virus that forms a mini-chromosome as its transcriptional template within the nucleus of hepatocytes. Therefore, HBV replication can be suppressed but the virus cannot be eliminated by nucleoside...

More than 240 million people worldwide are chronically infected with the hepatitis B virus (HBV) and are at risk of developing liver cirrhosis and hepatocellular carcinoma. HBV is a small, circular DNA virus that forms a mini-chromosome as its transcriptional template within the nucleus of hepatocytes. Therefore, HBV replication can be suppressed but the virus cannot be eliminated by nucleoside...

Abstract Tissue-resident memory CD4 T cells (TRM) protect against pathogens through the early shaping of inflammation at sites infection. The extent to which their activation can impact subsequent systemic cell responses is not clear. To ask if lung TRM recognizing antigen same presented in secondary lymphoid organs, we generated OVA-specific primed by infection with an influenza virus expressi...

Two multiscale (hybrid) stochastic reaction-diffusion models of actin dynamics in a filopodium are investigated. Both hybrid algorithms combine compartment-based and molecular-based stochastic reaction-diffusion models. The first hybrid model is based on the models previously developed in the literature. The second hybrid model is based on the application of a recently developed two-regime meth...