Depolymerization products of purified microtubules from porcine brain were examined by sedimentation analysis and electron microscopy. The complete depolymerization mixture exhibited 36S and 6S components in concentration-dependent equilibrium, whether depolymerization was caused by low temperature or by calcium ion. These components were recognized by electron microscopy as spirals and rings, ...

We constructed population pharmacokinetic (PK) models for the five constituents of daikenchuto (DKT), a traditional Japanese herbal medicine. Data were collected from two randomized PK studies conducted in Japan and the United States. Participants received single oral doses of 2.5 g, 5 g, and 10 g of DKT. The plasma concentrations of five DKT constituents--hydroxy-α-sanshool (HAS), hydroxyl-β-s...

Full (1)H and (13)C NMR chemical shift assignments were made for two sets of penam beta-lactams: namely, the diastereomeric (2S, 5S, 6S)-, (2S, 5R, 6R)-, (2S, 5S, 6R)-, and (2S, 5R, 6S)-methyl 6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylates (1-4) and (2S, 5R, 6R)-, (2S, 5S, 6R)-, and (2S, 5R, 6S)-6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4...

The -masses of the b-quarkonium system are analyzed relativistically in a linear plus Coulomb potential model in order to determine whether the observed T(11020) is the 6s (bb) state. The quark mass and the potential parameters are determined by the least squares method, comparing the calculated and the observed masses of the system. It has been found that the r(11020) state must be assigned to...

A glandular secretion of the civet cat, (2S,6S)-(6-methyltetrahydropyran-2-yl)acetic acid 1 and its enantiomer, were synthesized from the yeast-reduction product and recovered substrate from yeast reduction.

With a view to improved parity violation measurements in Cs, we have considered the 6S-7S-6P3/2 « forbidden three-level system », in which one laser excites the forbidden 6S-7S transition while a second, colinear laser probes the excited 7S atoms. This paper presents an analytical calculation of the 7S ~ 6P 1⁄2 fluorescence intensity and of the probe amplification as functions of the laser freq...

Introduction: Residual patient motion between images in breath-hold DCE-MRI may compromise image analysis such as the extraction of pharmacokinetic parameters. This work analyses results of the Progressive Principal Component Registration (PPCR) algorithm [1] on six 3D DCE-MRI datasets. These datasets are acquired at a temporal resolution of 12s consisting of a 6s breath-hold volume acquisition...

In this work, we present an adiabatic and nonadiabatic study for all the (1)Sigma(+) states dissociating below the ionic limits [i.e., Na (3s, 3p, 4s, 3d, 4p, 5s, 4d, 4f), K (4s, 4p, 5s, 3d, 5p, 4d, 6s, 4f) and Rb (5s, 5p, 4d, 6s, 6p, 5d, 7s, 4f) + H (1s)]. The ab initio calculations rely on pseudopotential, operatorial core valence correlation and full valence CI (configuration-interaction) ap...