Besides the conventional carbon sources, acetyl-CoA has recently been shown to be generated from acetate in various types of cancers, where it promotes lipid synthesis and tumour growth. The underlying mechanism, however, remains largely unknown. We find that acetate induces a hyperacetylated state of histone H3 in hypoxic cells. Acetate predominately activates lipogenic genes ACACA and FASN ex...

Introduction The methylation of CpG island in promoter and its nearby area is one the most important way to inhibit gene expression. aim this study was examine potential relationship between for fatty acid synthase (FASN) sterol regulatory element-binding protein 1 (SREBP-1). Material methods Ten newborn pups gerbils as NB group, 10 adult with normal diet control adults high-fat NAFLD 8-month-o...

Two SNPs, i.e. L127V and T172M, of bovine growth hormone (GH) causing the presence of GH gene haplotypes A, B, and C was previously shown to alter intramuscular fatty acid (FA) composition in Japanese Black (JB) heifers. To determine the SNP effect on somatotropic hormone concentration and lipogenesis, we measured plasma GH, insulin, and insulin-like growth factor-1 (IGF-1) concentrations. We a...

Fatty acid composition is one of the important traits in beef. The aim of this study was to identify candidate genomic regions for fatty acid composition by genome-wide association study with 50 K single nucleotide polymorphism (SNP) array in Japanese Black cattle. A total of 461 individuals and 40 657 SNPs were used in this study. We applied genome-wide rapid association using mixed model and ...

Extranodal natural killer (NK)/T-cell lymphoma is an aggressive malignant tumor with distinctive clinicopathological features, characterized by vascular invasion and destruction, prominent necrosis, cytotoxic lymphocyte phenotype and a strong association with Epstein-Barr virus. Here is reported an extranodal nasal NK/T-cell lymphoma case, involving the maxillary sinus, floor of the orbit, and ...

Using a rat model, we investigated factors contributing to the pathogenesis of irinotecan-associated fatty liver disease. Male Sprague-Dawley rats were administered 200 mg/kg irinotecan by intraperitoneal injection on days 1-4, but not on days 5-7. This schedule was repeated 3 times. Rats were sacrificed 4, 18 and 25 days after the last injection, and liver steatosis was evaluated by hematoxyli...

Purpose: Fatty acid synthase (FASN) is overexpressed in human breast carcinoma. Auth Biom Cièn Facu M.D d'On Bioq Barce Rece Gran RD06 T. Pu Colom 10, T dad A Span de la from Clin The natural polyphenol (-)-epigallocatechin-3-gallate blocks in vitro FASN activity and leads to apoptosis in breast cancer cells without any effects on carnitine palmitoyltransferase-1 (CPT-1) activity, and in vivo, ...

To improve beef quality, a selection of specific breeds for crossbreeding, genotyping, and candidate genes in breeding animals can be some the solutions. The objective this study was to determine effects FASN, SCD, GH on carcass fatness fatty acid (FA) composition intramuscular lipids crossbred Holstein × (Simmental, Belgian Blue, Limousin, Piemontese). allelic genotypic distribution polymorphi...