Mitochondria, cellular organelles playing essential roles in eukaryotic cell metabolism, are thought to have evolved from bacteria. The organization of mtDNA is remarkably uniform across species, reflecting its vital and conserved role in oxidative phosphorylation (OXPHOS). Our objectives were to evaluate the compatibility of xenogeneic mitochondria in the development of preimplantation embryos...

The complete sequence of the mitochondrial (mt) genome of the assassin bug, Sirtheneaflavipes (Stål), was determined. The circular genome is 15, 961 bp long and contains a standard gene complement, i.e., the large and small ribosomal RNA (rRNA) subunits, 22 transfer RNA (tRNA) genes, 13 protein-coding genes (PCGs), and the 1, 295 bp control region. The nucleotide composition of S. flavipes mt g...

Common inbred strains of the laboratory rat can be divided into four different mitochondrial DNA haplotype groups represented by the SHR, BN, LEW, and F344 strains. In the current study, we investigated the metabolic and hemodynamic effects of the SHR vs. LEW mitochondrial genomes by comparing the SHR to a new SHR conplastic strain, SHR-mt(LEW); these strains are genetically identical except fo...

Isolated Complex I (CI) deficiency, the most frequent cause of mitochondrial disease, is a clinically and genetically heterogeneous condition. Complex I is a giant multiheteromeric enzyme composed of seven ND subunits encoded by mitochondrial DNA (mtDNA) genes, and at least 38 subunits encoded by nuclear genes. To establish the contribution to human mitochondrial encephalopathy of ND versus nuc...

AIMS AND BACKGROUND Various genes have been identified for monogenic disorders resembling Parkinson's disease. The products of some of these genes are associated with mitochondria and have been implicated in cellular protection against oxidative damage. In the present study we analysed fibroblasts from a patient carrying the homozygous mutation p.W437X in the PTEN-induced kinase 1 (PINK1), whic...

The C(C,a) reaction at 22 MeV was used to study T52 Ne. Charged particles were detected with a Si detector telescope at 0°, and g transitions in coincidence were detected with an array of three Comptonsuppressed ‘‘clover’’ detectors and seven Compton-suppressed single Ge crystals. The a-g and a-g-g coincidence data were analyzed to study the structure of Ne. Twenty-two new g lines were assigned...

Eritrea has one of the northernmost populations of African elephants. Only about 100 elephants persist in the Gash-Barka administrative zone. Elephants in Eritrea have become completely isolated, with no gene flow from other elephant populations. The conservation of Eritrean elephants would benefit from an understanding of their genetic affinities to elephants elsewhere on the continent and the...

PURPOSE Many solid tumors exhibit abnormal aerobic metabolism characterized by increased glycolytic capacity and decreased cellular respiration. Recently, mutations in the nuclear encoded mitochondrial enzymes fumarate hydratase and succinate dehydrogenase have been identified in certain tumor types, thus demonstrating a direct link between mitochondrial energy metabolism and tumorigenesis. Alt...

The invasive Asian tiger mosquito Aedes albopictus (Diptera: Culicidae) was first reported in central Africa in 2000, in Cameroon, with the indigenous mosquito species Ae. aegypti (Diptera: Culicidae). Today, this invasive species is present in almost all countries of the region, including the Central African Republic (CAR), where it was first recorded in 2009. As invasive species of mosquitoes...

Abstract The aim of this study was to identify molecular defects caused by mutations in mitochondrial DNA cases recurrent and multiple canine tumours. We presented differences the mtDNA genome for two tumours observed different body parts 5 dogs throughout time case recurrence. Mitochondrial sequenced on an Illumina MiSeq sequencer using a 600-cycle kit paired-end mode targeting at least 100x c...