AIMS To assess the risk of acute pancreatitis associated with use of acid-suppressing drugs. METHODS We conducted a retrospective cohort study with a nested case-control design within the General Practice Research Database (GPRD) in the United Kingdom. The cohort included 180 178 persons aged 20-74 years, who had received at least one prescription of cimetidine, famotidine, nizatidine, raniti...

BACKGROUND AND AIMS The burden of premature mortality due to opioid-related death has not been fully characterized. We calculated temporal trends in the proportion of deaths attributable to opioids and estimated years of potential life lost (YLL) due to opioid-related mortality in Ontario, Canada. DESIGN Cross-sectional study. SETTING Ontario, Canada. PARTICIPANTS Individuals who died of ...

BACKGROUND Parkinson's disease is a common disorder among older people. Accurate epidemiological information is essential to identify possible aetiological factors, plan health services and set priorities for medical research. OBJECTIVE to determine the incidence of idiopathic Parkinson's disease in a defined geographical area in the North-East of England. METHODS using a prospective, longi...

Dementia is defined by acquired, progressive impairment in two or more cognitive areas (for example, frontal executive function, mood, or memory) that is severe enough to render a person dependent on others. Dementia is a leading cause of disability among older adult patients; Alzheimer disease is the most common etiology. The prevalence of Alzheimer disease is approximately 2% among persons 60...

The health risks of obesity are summarized in terms of disease in Fig. 1. Obesity is associated with a higher mortality incidence from cerebrovascular disease, coronary heart disease, diabetes mellitus and cancer of the breast, colon, endometrium and prostate (Lew & Garfinkel, 1979). Potent cardiovascular disease risk factors such as hypertension and hypercholesterolaemia have also been associa...

BACKGROUND Injection drug use (IDU) is important in the epidemiology of blood-borne pathogens. Herein, trends in IDU from 1979 to 2002 are analyzed. METHODS The National Household Survey on Drug Abuse is an ongoing survey of drug use among the US population 12 years and older. Participants were chosen using a multistage sampling design and interviewed by written questionnaire (1979-1998) or a...

The Prime Power Conjecture (PPC) states that abelian planar diierence sets of order n exist only for n a prime power. Evans and Mann 2] veriied this for cyclic diierence sets for n 1600. In this paper we verify the PPC for n 2;000;000, using many necessary conditions on the group of multipliers.