The level set method was devised by Osher and Sethian in [64] as a simple and versatile method for computing and analyzing the motion of an interface Γ in two or three dimensions. Γ bounds a (possibly multiply connected) region Ω. The goal is to compute and analyze the subsequent motion of Γ under a velocity field v. This velocity can depend on position, time, the geometry of the interface and ...

PURPOSE To develop and validate an intermittent match-fitness test for water-polo players. METHODS Eight male junior players performed the Water Polo Intermittent Shuttle Test (WIST) twice to assess test reliability. To assess test sensitivity and validity, 104 male and female players from different competition standards and playing positions were tested. Eighteen players performed the WIST 5...

Background: The effects of interferon1b (IFN1b ) administration in multiple sclerosis (MS) patients have been confirmed, however, those in neuromyelitis optica (NMO) patients have not been shown. In this study, we assessed the effects of IFN1b treatment on disease exacerbation and disability progression in MS or NMO patients. Methods: We reviewed a series of 104 consecutive patients with relaps...

PURPOSE To investigate the prognostic and predictive significance of subtyping node-positive early breast cancer by immunohistochemistry in a clinical trial of a docetaxel-containing regimen. METHODS Pathologic data from a central laboratory were available for 1,350 patients (91%) from the BCIRG 001 trial of docetaxel, doxorubicin, and cyclophosphamide (TAC) versus fluorouracil, doxorubicin, ...

Since the seminal work of [92] on coupling the level set method of [69] to the equations for two-phase incompressible flow, there has been a great deal of interest in this area. That work demonstrated the most powerful aspects of the level set method, i.e. automatic handling of topological changes such as merging and pinching, as well as robust geometric information such as normals and curvatur...

This paper surveys recent work by the author on the theoretical and algorithmic aspects of restless bandit indexation as well as on its application to a variety of problems involving the dynamic allocation of priority to multiple stochastic projects. The main aim is to present ideas and methods in an accessible form that can be of use to researchers addressing problems of such a kind. Besides b...

Consideration of the question of meaning in the framework of linguistics often requires an allusion to sets and other higher-order notions. The traditional approach to representing and reasoning about meaning in a computational setting has been to use knowledge representation systems that are either based on first-order logic or that use mechanisms whose formal justifications are to be provided...

BACKGROUND 3-bromopyruvate (3-BrPA) and dichloroacetate (DCA) are inhibitors of cancer-cell specific aerobic glycolysis. Their application in glioma is limited by 3-BrPA's inability to cross the blood-brain-barrier and DCA's dose-limiting toxicity. The safety and efficacy of intracranial delivery of these compounds were assessed. METHODS Cytotoxicity of 3-BrPA and DCA were analyzed in U87, 9L...

OBJECTIVE To test whether rs1990622 (TMEM106B) is associated with age at onset (AAO) in granulin (GRN) mutation carriers and with plasma GRN levels in mutation carriers and healthy, elderly individuals. Rs1990622 (TMEM106B) was identified as a risk factor for frontotemporal lobar degeneration with TAR DNA-binding protein inclusions (FTLD-TDP) in a recent genome-wide association. DESIGN Rs1990...

TOPIC: Chest Infections TYPE: Fellow Case Reports INTRODUCTION: Nontuberculous mycobacterium (NTM) associated pulmonary infections are a rising cause for concerns globally. There has been surge of NTM reported cases in the United States over past decade. The most common from isolated due to Mycobacterium avium complex (MAC), kansasii, and abscessus. fortuitum group species subset rapid growing ...