Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a critical role in the pathogenesis of a variety of proliferative vascular diseases. Recently, we have found that microRNA (miRNA) miR-145 is the most abundant miRNA in normal vascular walls and in freshly isolated VSMCs; however, the role of miR-145 in VSMC phenotypic modulation and vascular diseases is currently unknown. Here...

A 63-year-old man presented with painless jaundice, loss of appetite and significant weight loss. Cross-sectional imaging showed a diffusely enlarged pancreas, with no significant fat stranding and a hypodense rim on computed tomography, which appeared hypointense on T2-weighted magnetic resonance imaging. There was a narrowed pancreatic duct and features of common bile duct narrowing in the re...

The rapid emergence of strains of Enterococcus faecium with high-level resistance to vancomycin (VREF) has created a serious therapeutic void in the management of enterococcal infection. As for vancomycin-susceptible enterococci, serious infection with VREF strains frequently occurs in debilitated or immunocompromised hosts with significant underlying disease. Several recent series report an in...

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 128 The Linnaean perspective on Cnidarian diversity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 128 Modern perspectives on Cnidarian diversity . . . . . . . . . . ...

MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression and play an important role in many developmental processes. We report here that expression of microRNA-145 (miR-145) is low in self-renewing human embryonic stem cells (hESCs) but highly upregulated during differentiation. We identify the pluripotency factors OCT4, SOX2, and KLF4 as direct targets of miR-145 and show that ...

The in vitro biological activities of the ethyl acetate extract culture filtrate from Streptomyces achromogenes TCH4 (TCH4 extract) were evaluated. produced a bacteriostatic effect against Enterobacter cloacae, Staphylococcus aureus, saprophyticus, Bacillus subtilis, methicillin-resistant S. aureus (MRSA) and Klebsiella pneumoniae. had bactericidal activity K. pneumoniae with minimum concentrat...

two studies were conducted to evaluate the correlation between growth performance of chicks fed full fat soybean (ffsb) extruded at 145, 155 and o 165 and laboratory quality tests. in biological study, one hundred and forty four d-old male broiler chicks were divided into 12 groups including 3 treatments with 4 replicates of 12 chicks each and fed three diets containing 15 % ffsb extruded at 14...

E. D. CLARKE*, L. B. SPEAR†, M. L. MCCRACKEN‡, F. F. C. MARQUES*, D. L. BORCHERS*, S. T. BUCKLAND* and D. G. AINLEY† * Centre for Research into Ecological and Environmental Modelling, University of St Andrews, The Observatory, Buchanan Gardens, Fife KY16 9LZ, UK; † H.T. Harvey & Associates Ecological Consultants, 3150 Almaden Expwy, Suite 145, San Jose, CA 95118, USA; and ‡ National Marine Fish...

Twenty-two surface sediment samples were collected from Visakhapatnam harbour, east coast of India, and analysed for monophenyltin (MPT), diphenyltin (DPT), triphenyltin (TPT), total bacteria, and TPT tolerant bacteria. Concentrations of MPT, DPT and TPT varied between 1-26, 3-28, and 0.31-145 ng Sn g(-1) dry wt, respectively. Phenyltin concentrations were influenced by ship related activities,...

Laboratory tests (March 4) revealed hemoglobin 11.3 g/ dl, hematocrit 35%, mean corpuscular volume 85 fL, platelet 281,000/mm3, leukocytes 14,400/mm (neutrophils 81%, eosinophils 1%, lymphocytes 11% and monocytes 7%), creatinine 0.93 mg/dl, urea 42 mg/dl, sodium 145 mEq/l, potassium 3.4 mEq/l, C-reactive Protein 172 mg/l, troponin I < 0.20 ng/ml, CKMB 2,17 ng/ml, prothrombin time (INR) 1.2 and ...