Abstract Introduction The mean systemic estradiol value in menopausal women is < 10 pg/ml, consistent with ovarian failure. Such low values are associated multiple symptoms including hot flashes, night sweats, insomnia, mood changes and irritability, cognitive changes, weight gain slowed metabolism. Contemporary management estradiol, maximizing safety efficacy, emphasizes non-oral, non-i...

A study on performance of seven mandarin genotypes along with BARI Komala-1 as check was carried out at the Citrus Research Station, Bangladesh Agricultural Institute (BARI), Jaintapur, Sylhet from January 2016 to December 2018. The average highest number fruits per plant (37.2), and maximum fruit yield (6.19 kg) hectare (6.87 t) were recorded in genotype CR Jai-017. largest (189.67 g) found Ja...

The authors thank OpenEye Scientific Software Inc., ChemAxon, and Cepos Insilico Ltd. for providing Academic Licences for ROCS, JChem, and PARASURF, respectively. This work is funded by the Agence Nationale de la Recherche, grant reference ANR-08-CEXC-017-01. VIPN is grateful for a Marie Curie IEF Fellowship. A) The target structures were first superposed onto the crystallographic query using P...