The vascular wall has the capacity to produce thromboxane A2. However, the role of vascular thromboxane A2 is still uncertain. In this study, we examined the relationship between vascular thromboxane A2 generation and vascular smooth muscle cell growth in spontaneously hypertensive rats (SHR). Vascular thromboxane A2 generation was significantly enhanced by 49% in 5-week-old and by 117% in 15-w...

ii NOTICE The U.S. Environmental Protection Agency through its Office of Research and Development partially funded and collaborated in the research described here under Cooperative Agreement No. CR-822204 to the University of California, Davis. It has been subjected to the Agency's peer and administrative review and has been approved for publication as an EPA document. Mention of trade names or...

We address the question: \Are some classes of combinatorial optimization problems intrinsically harder than others, without regard to the algorithm one uses, or can diiculty only be assessed relative to particular algorithms?" We provide a measure of the hardness of a particular optimization problem for a particular optimization algorithm and present two algorithm-independent quantities that us...

We study the geometric shortest path and the minimum spanning tree problem with neighborhoods in the L1 metric. In this setting, we are given a graph G = (R, E), where R = {R1, . . . , Rn} is a set of polygonal regions in the plane. Placing a point pi inside each region Ri turns G into an edge-weighted graph Gp, p = {p1, . . . , pn}, where the cost of an edge is the distance between the points....

Background: SP110 plays an important role in microbial immunity and regulating macrophage biological activity, which may protect against tuberculosis. To investigate whether SNPs of are associated with susceptibility to latent TB infection Iraq population. Hence, identifying these genes could be used as a marker screen individuals at risk Infection. Method: A case-control study was conducted th...

Platelets are suggested to exacerbate ischemia-induced myocardial injury, which has led to the study of various antiplatelet therapies including thromboxane synthetase inhibitors (TXSI). Two such agents, benzylimidazole and OKY-046, reduce infarct size commensurate with a diminution in serum thromboxane B2 formation in anesthetized dogs subjected to 90 minutes of coronary artery occlusion follo...

OBJECTIVE To evaluate Merkel cell polyomavirus (MCPyV) DNA prevalence and load among men with human immunodeficiency virus (HIV) (hereafter referred to as HIV-positive men) and among healthy male control subjects. DESIGN Prospective study from February 4, 2009, through April 24, 2010. SETTING Dermatology department of a university hospital. PATIENTS A total of 449 male adults were prospec...

The success of the first approved kinase inhibitor imatinib has spurred great interest in the development of type II inhibitors targeting the inactive DFG-out conformation, wherein the Phe of the DFG motif at the start of the activation loop points into the ATP binding site. Nevertheless, kinase inhibitors launched so far are heavily biased toward type I inhibitors targeting the active DFG-in c...

PURPOSE To evaluate the usefulness of dynamic susceptibility contrast (DSC) enhanced perfusion MR imaging in predicting major genetic alterations in glioblastomas. MATERIALS AND METHODS Twenty-five patients (M:F = 13∶12, mean age: 52.1±15.2 years) with pathologically proven glioblastoma who underwent DSC MR imaging before surgery were included. On DSC MR imaging, the normalized relative tumor...