The inhibitory effects of 20 selected antiviral compounds on the replication of adenoviruses (types 1 to 8) in vitro were investigated. While 18 compounds were ineffective, 2 compounds, namely (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA] and 9-[(2-hydroxy-1,3,2-dioxaphosphorinan-5-yl)oxymethyl]guanine P-oxide (2'-nor-cyclic GMP), were highly effective against all adenovirus ty...

The 9-phenyland the 9-(p-tolyl)-xanthen-9-yl groups 2a and 2b are recommended as alternatives to the 4,40-dimethoxytrityl group 1 for the protection of the 50-hydroxy functions in oligonucleotide synthesis. 2004 Elsevier Ltd. All rights reserved.

A carpin (3-hydroxy-9-methoxypterocarpan) (Medicarpin) (1) and four isoflavones, 7-hydroxy-4'-methoxy-isoflavone (Formononetin) (2); 7,4'-dimethoxyisoflavone (3); 5,4'-dihydroxy-7-methoxy-isoflavone (Prunetin) (4) and 7-hydroxy-6,4'-dimethoxyisoflavone (5) were isolated from the tuber roots of Butea superba Roxb. Compounds 2 and 4 showed moderate cytotoxic activity on KB cell lines with IC(50) ...

Four new ursane-type triterpenes, 3beta-acetoxy-11alpha-methoxy-12-ursene (1), 3beta-acetoxy-11alpha-ethoxy-12-ursene (2), 3beta-acetoxy-11alpha-hydroperoxy-12-ursene (3), 3beta-hydroxy-11alpha-hydroperoxy-12-ursene (4), and two new oleanane-type triterpenes, 3beta-acetoxy-11alpha-ethoxy-12-oleanene (5), 3beta-acetoxy-111alpha-hydroperoxy-12-oleanene (6), together with 3beta-acetoxy-11alpha-hyd...

Black nightshade (Solanum nigrum L.) has been traditionally used as indigenous Chinese medicine. Phytochemical investigations of the immature fruits S. have carried out and nine phenylpropanoids (1-9) were obtained. Their structures elucidated on basis spectroscopic chemical methods, including MS, 1H 13C-NMR. They identified (7S, 8R)-4-[3-hydroxymethyl-5-(3- hydroxypropyl)-2,3-dihydrobenzofuran...

Previous reports that radioactivity was bound to liver RNA after administration of 2-acetylaminofluorene-9-14C or N-hydroxy-2-acetylaminofluorene-9-14C in species susceptible to the carcinogenic action of 2-acetylaminofluorene have been con firmed. Injection of l-hydroxy-2-acetylaminofluorene-l-14C, a noncarcinogenic metabolite of 2-acetylaminofluorene, did not result in any binding of radioact...

Microorganisms (17 bacteria and 3 fungi) isolated from crude oil-contaminated soils were evaluated for degradation of five polyaromatic hydrocarbons (PAHs), both in the absence (-T80) presence surfactant Tween-80 (+T80) at a 10 mg L?1 concentration each PAH. Results heat map Tukey HSD revealed that highest PAH was observed by Kocuria rosea +T80 treatment. Degradation (%) individual (-T80, +T80)...

Wastewater treatment plants are increasingly interested in adopting inorganic coagulants and organic flocculants their sludge process since disposal costs more than half of the overall operational costs. This study synthesized poly titanium sulfate (PTS) by different molar ratios used best one with cellulose-based for conditioning. PTS a 1:2 ratio showed lowest capillary suction time (CST) was ...