Despite their differences in physicochemical properties, both uranium (U) and fluoride (F) are nephrotoxicants at high doses but adverse effects low still the subject of debate. METHODS: This study aims to improve knowledge biological mechanisms involved through an adaptive response model C57BL/6 J mice chronically exposed priming U (0, 10, 20 40 mg/L) or F 15, 30 50 then challenged with acute ...

Organisms around the globe are experiencing novel environments created by human activities. One such disturbance of growing concern is the salinization of freshwater habitats from the application of road deicing salts, which creates salinity levels not experienced within the recent evolutionary history of most freshwater organisms. Moreover, salinization can induce trophic cascades and alter th...

We report an isocratic "high-performance" liquid-chromatographic (HPLC) procedure for measurement of five orally administered cephalosporins (cefixime, cefaclor, cefadroxil, cephalexin, and cephradine) in 0.1 mL of human serum. Serum protein is precipitated with acetonitrile, the sample is centrifuged, and the supernate is evaporated under nitrogen. The residue is reconstituted in 0.1 mL of mob...

Os exames laboratoriais (6/3/2002) revelaram: hemoglobina 18,6 g/dl, hematócrito 59%, hemácias 6.100.00/mm3, leucócitos 6.100/mm3, creatinina de 1,3 mg/dl, sódio de 129 mEq/l e potássio 3,4 mEq/l; glicemia 108 mg/dl, colesterol 183 mg/dl (HDL de 49 mg/dl, LDL 103 mg/dl), triglicérides de 155 mg/dl, AST de 10 U/l, ALT de 15 U/l, TSH de 4,3 (normal de 0,3 a 4,5) μU/ml, T3 de 0,6 (normal de 0,8 a ...

The alternative use of natural products, like royal jelly (RJ), may be an important tool for the treatment of infections caused by antibiotic-resistant bacteria. RJ presents a large number of bioactive substances, including antimicrobial compounds. In this study, we carried out the chemical characterization of fresh and lyophilized RJ and investigated their antibacterial effects with the purpos...

This study evaluated whether the caudate-putamen dopamine response that has been observed after deprenyl administration could be attributed exclusively to metabolically generated l-methamphetamine (l-MeAmp). Brain and plasma levels of deprenyl and l-MeAmp were measured after deprenyl (10 mg/kg s.c.) from 10 to 60 min in conscious rats. Peak caudate-putamen levels were observed for deprenyl (15 ...

BACKGROUND Chemical speciation analysis is essential for the biological monitoring of inorganic arsenic exposure using urine as indicator medium. There is increasing demand for a certified reference material (CRM) of urine matrix for arsenic speciation. METHODS Urine (10 L) was collected from non-occupationally exposed Japanese males. We prepared 954 bottles of urine, each containing approxim...

When presenting, the haemoglobin level was 8.1 g/dl, reticulocytes 0.4%, white blood cell count 17.6 × 10 cells/l with 4% blast cells, 2% myelocytes, 77% polymorphonuclear leukocytes, 5% band cells, 6% monocytes and 7% lymphocytes. The platelet count was 30 × 10/l. Further laboratory tests revealed a lactate dehydrogenase (LDH) level of 251 U/l (normal < 250 U/l), a serum ferritin level of 4720...

Banana blossom is a source of anthocyanin that potentially utilized as natural dyes in the food industry. Anthocyanin from banana can be extracted using Ultrasonic Assisted Extraction (UAE) and maceration method. ultrasonic causes cavitation effect thereby provide an efficiency extraction time if compared with This study aimed to determine duration sonication treatment on total extract. Experim...

M e t h o d s Design: Randomized placebo-controlled trial (Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication [DREAM]). Allocation: Concealed.* Blinding: Blinded (clinicians, patients, data collectors, and outcome assessors).* Follow-up period: Median 3 years. Setting: 191 centers in 21 countries. Patients: 5269 patients ≥ 30 years of age (mean age 55 y, 59% women) who had...